In this project, we are developing and testing new protocols for simulating vibrational chiroptical spectra – vibrational circular dichroism and Raman optical activity – of glycans and related compounds in solution.  Such protocols involve sampling molecular dynamics trajectories and subsequent quantum chemical analysis of the resulting snaphots.  The current state of the project is focused on benchmarking along several related axes, including the choices of basis set and density functional, the number of snapshots along the trajectory, and the number of explicit solvent molecules to retain surrounding the solute.