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Log in and create a chronicleThe unusual cell wall of the Lyme disease spirochaete Borrelia burgdorferi is shaped by a tick sugar
Tanner G. DeHart, Mara R. Kushelman, Sherry B. Hildreth, Richard F. Helm &...
Department of Biochemistry, Virginia Tech, Blacksburg, VA, USA
Fralin Life Sciences ...
FurC (PerR) contributes to the regulation of peptidoglycan remodeling and intercellular molecular transfer in the cyanobacterium Anabaena sp. strain PCC 7120
Cristina Sarasa-Buisan,1,2 Mercedes Nieves-Morión,2 Sergio Arévalo,2 Richard F. ...
1 Departamento de Bioquímica y Biología Molecular y Celular, Facultad de Ciencia...
Coarse-grained molecular dynamics integrated with convolutional neural network for comparing shapes of temperature sensitive bottlebrushes
SY Joshi, S Singh, SA Deshmukh
Department of Chemical Engineering, Virginia Tech, Blacksburg, VA, 24061, USA
Toward Automatic Inference of Glycan Linkages Using MSn and Machine Learning - Proof of Concept Using Sialic Acid Linkages
Xinyi Ni, Nathan B. Murray, Stephanie Archer-Hartmann, Lauren E. Pepi, Richard F. Helm, Parast...
Pregnancy enables antibody protection against intracellular infection
John J. Erickson, Stephanie Archer-Hartmann, Alexander E. Yarawsky, Jeanette...
Predicting the stereoselectivity of chemical reactions by composite machine learning method
Jihoon Chung1, Justin Li2, Amirul Islam Saimon3, Pengyu ...
1Department of Industrial Engineering, Pusan National University, Busan, Korea.
...Comparative mucomic analysis of three functionally distinct Cornu aspersum Secretions
Antonio R. Cerullo1,2,3, Maxwell B. McDermott3, Lauren E. Pepi4
1The Advanced Science Research Center, Graduate Center of the City University of Ne...
All-polysaccharide, self-healing, pH-sensitive, in situ-forming hydrogel of carboxymethyl chitosan and aldehyde-functionalized hydroxyethyl cellulose
Rafael F.N. Quadrado a, Zhenghao Zhai b, M...
a Laboratório de Tecnologia e Desenvolvimento de Compósitos e Materia...
Identification of a new family of peptidoglycan transpeptidases reveals atypical crosslinking is essential for viability in Clostridioides difficile
Kevin W. Bollinger1 , Ute Müh1 , Karl L. Ocius2 , Alexis J. Apostol...
1. Department of Microbiology and Immunology Carver College of Medicine University of Iowa Iow...
Protein−Ligand CH−π Interactions: Structural Informatics, Energy Function Development, and Docking Implementation
Yao Xiao, Robert J. Woods
The Complex Carbohydrate Research Center, University of Georgia
Synthesis and Characterization of Multi-Reducing-End Polysaccharides
Zhenghao Zhai‡1, Yang Zhou‡2, Andrew G. Korovich1,3
Development, Validation, and Applications of Nonbonded Interaction Parameters between Coarse-Grained Amino Acid and Water Models
Esmat Mohammadi, Soumil Y. Joshi, Sanket A. Deshmukh
Department of Chemical Engineering, Virginia Tech, Blacksburg, Virginia 24061, United States
Rapid, Autonomous High-throughput Characterization of Hydrogel Rheological Properties via Automated Sensing and Physics-guided Machine Learning
Junru Zhang a, Yang Liu a b,&nb...
a Grado Department of Industrial and Systems Engineering, Virginia Tech, Blacksburg, VA 24061 ...
Host heparan sulfate promotes ACE2 super-cluster assembly and enhances SARS-CoV-2-associated syncytium formation
Qi Zhang, Weichun Tang, Eduardo Stancanelli, Eunkyung Jung, Zulfeqhar Syed...
1 Laboratory of Molecular Biology, National Institute of Diabetes, Digestive, and Kidney Disea...
Synthesis and real-time characterization of self-healing, injectable, fast-gelling hydrogels based on alginate multi-reducing end polysaccharides (MREPs)
Zhenghao Zhai a.,Yang Zhou b,Ishani Sarkar e,Yang Liu a<...
a. Macromolecules Innovation Institute, Virginia Tech, Blacksburg, VA 24061, United State...
Imbalanced spectral data analysis using data augmentation based on the generative adversarial network
Jihoon Chung1, Junru Zhang2, Amirul Islam Saimon2, Yang Liu 1Department of Industrial Engineering, Pusan National University, Busan, South Kore...
On the use of property-oriented basis sets for the simulation of vibrational chiroptical spectroscopies
Brendan M. Shumbergera, Ethan H. Finka,RollinA.Kingb and T. D...
a. Department of Chemistry, Virginia Tech, Blacksburg, Virginia, U.S.A.
b. Departmen...
Regioselective and controlled-density branching in amylose esters
Jeffrey E. Thompson a, Kevin J. Edgar a a Macromolecules Innovation Institute, Virginia Tech, Blacksburg, VA 24061, Un...
Seaweed-derived fucoidans and rhamnan sulfates serve as potent anti-SARS-CoV-2 agents with potential for prophylaxis
Yuefan Song a, Amit Singh b, Maisha M.&nbs...
a Center for Biotechnology & Interdisciplinary Studies, Rensselaer Polytec...
Chlorination of hydroxyethyl cellulose enables selective functionalization
Chengzhe Gao, Stella P. Petrova, and Kevin J. Edgar
C. Gao · S. P. Petrova Department of Chemistry, Virginia...
Polyproline peptide targets Klebsiella pneumoniae polysaccharides to collapse biofilms
Laura De los Santos 1, Robert L. Beckman IV 1
1 Division of Immunity and Pathogenesis, Burnett School of Biomedical Sciences, Col...
Probing the Role of Protein Conformational Changes in the Mechanism of Prenylated-FMN-dependent Phenazine-1-carboxylic Acid Decarboxylase
Prathamesh M. Datar 1, Soumil Y. Joshi 2, ...
1 Department of Chemistry, University of Michigan, Ann Arbor, Michigan, USA
Heparin Specifically Inhibits CRISPR/Cas12 Activation, Enabling Ultrasensitive Heparin Detection and Gene Editing Regulation
Min Cao, Xinlan Bian, Zhirun Ji, Muhammad Sohail, Fuming Zhang, Robert J. Linhardt, Bingzhi Li...
Min Cao − School of Food Science and PharmaceuticalEngineering, Nanjing Normal Universit...
Sulfated fuco-manno-glucuronogalactan alleviates pancreatic beta cell senescence via PI3K/AKT/FoxO1 pathway
Wenjing Zhang a 1, Nan Wu a&nbs...
aDepartment of Endocrinology and Metabolism, Sir Run Run Shaw Hospital, Zhejiang Un...
Fibrolamellar Carcinomas–Growth arrested by paracrine signals complexed with synthesized 3-O sulfated heparan sulfate oligosaccharides
Wencheng Zhang a b c d&nb...
aDepartment of Cell Biology and Physiology, University of North Carolina, Chapel Hi...
Structural Characteristics of Heparin Binding to SARS-CoV-2 Spike Protein RBD of Omicron Sub-Lineages BA.2.12.1, BA.4 and BA.5
Deling Shi1,2, Changkai Bu1, Peng He2, Yuefan Song2
1National Glycoengineering Research Center, Shandong University, Qingdao 266237, Ch...
Chemoenzymatic synthesis of sulfur-linked sugar polymers as heparanase inhibitors
Peng He, Xing Zhang, Ke Xia, Dixy E. Green, Sultan Baytas, Yongmei Xu...
Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, 110 ...
The diverse role of heparan sulfate and other GAGs in SARS-CoV-2 infections and therapeutics
Friederike Eilts a b 1, Sarah B...
aDepartment of Chemical and Biological Engineering, Center for Biotechnology and In...
Soluble α-klotho and heparin modulate the pathologic cardiac actions of fibroblast growth factor 23 in chronic kidney disease
Christopher Yanucil 1, Dominik Kentrup 1 <...
1Division of Nephrology, Department of Medicine, The University of Alabama at Birmi...
Ionically Complexed Nanoparticles for Heparin Oral Delivery
Bhagyashree Subramaniam, Nicole Leonick, Varenya Gade, David M. Frey, Fuming Zhang, Robert J. ...
Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, USA
...
Interactions of marine sulfated glycans with antithrombin and platelet factor 4
Wenjing Zhang, Weihua Jin, Vitor Hugo Pomin, Fuming Zhang, Robert J. Linhardt
1Department of Endocrinology, Sir Run Run Shaw Hospital, Zhejiang University School...
Interactions between heparin and SARS-CoV-2 spike glycoprotein RBD from omicron and other variants
Gelbach, Adrianne L., Fuming Zhang, Seok-Joon Kwon, John T. Bates, Andrew P. Farmer, Jonathan ...
1Department of Biological Sciences, Center for Biotechnology and Interdisciplinary ...
Graph–Graph Similarity Network
Han Yue, Pengyu Hong, Hongfu Liu
Michtom School of Computer Science, Brandeis University, Waltham, MA, USA
Fractionation of sulfated galactan from the red alga Botryocladia occidentalis separates its anticoagulant and anti-SARS-CoV-2 properties
Seon Beom Kim 1, Mary Zoepfl 2, Priyanka&n...
Expedient Synthesis of a Library of Heparan Sulfate-Like “Head-to-Tail” Linked Multimers for Structure and Activity Relationship Studies
Dr. Jicheng Zhang, Dr. Li Liang, Dr. Weizhun Yang, Dr. Sherif Ramadan, Dr....
Department of Chemistry, Michigan State University, East Lansing, MI 48824 USA
Depar...
Enzymatic synthesis of low molecular weight heparins from N-sulfo heparosan depolymerized by heparanase or heparin lyase
Yanlei Yu a, Li Fu b e, Pe...
College of Pharmaceutical Science & Collaborative Innovation Center for Yangtze River Delt...
Effect of high glucose on glycosaminoglycans in cultured retinal endothelial cells and rat retina
Gaganpreet Kaur, Yuefan Song, Ke Xia, Kevin McCarthy, Fuming Zhang, R...
Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Ce...
Computationally guided conversion of the specificity of E-selectin to mimic that of Siglec-8
Xiaocong Wang, Melinda S. Hanes, Richard D. Cummings, and Robert J.&n...
Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricult...
Comparison of Bulk- vs Layer-by-Layer-Cured Stimuli-Responsive PNIPAM–Alginate Hydrogel Dynamic Viscoelastic Property Response via Embedded Sensors
Yang Liu, Keturah Bethel, Manjot Singh, Junru Zhang, Rana Ashkar, Eric M. Davis, Blake N. John...
Grado Department of Industrial and Systems Engineering, Virginia Tech, Blacksburg, Virginia 24...
Cholesterol Chip for the Study of Cholesterol–Protein Interactions Using SPR
Peng He1,2,†, Shannon Faris1,2,†, Reddy Sudheer Sagabala
Anti-SARS-CoV-2 and anticoagulant properties of Pentacta pygmaea fucosylated chondroitin sulfate depend on high molecular weight structures
Rohini Dwivedi, Poonam Sharma, Friederike Eilts, Fuming Zhang, Robert J Li...
Department of BioMolecular Sciences, University of Mississippi, Oxford, Mississippi 38677...
A Cluster Sequencing Strategy To Determine the Consensus Affinity Domains in Heparin for Its Binding to Specific Proteins
Deling Shi, Anran Sheng, Changkai Bu, Zizhe An, Xueying Cui, Xiaojun Sun, Hongmei Li, Fuming Z...
National Glycoengineering Research Center, Shandong University, Qingdao, Shandong Province 266...
Knowledgebra: An Algebraic Learning Framework for Knowledge Graph
Yang, Tong, Yifei Wang, Long Sha, Jan Engelbrecht, and Pengyu Hong
Department of Physics, Boston College, Chestnut Hill, MA 02135, USA
Department of Co...
Chemoenzymatic Synthesis of Homogeneous Heparan Sulfate and Chondroitin Sulfate Chimeras
Eduardo Stancanelli, Wei Liu, Rylee Wander, Jine Li, Zhangjie Wang, Katelyn Arnold, Guowei Su,...
Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University ...
Structural and Substrate Specificity Analysis of 3-O-Sulfotransferase Isoform 5 to Synthesize Heparan Sulfate
Rylee Wander, Andrea M. Kaminski, Zhangjie Wang, Eduardo Stancanelli, Yongmei Xu, Vijayakanth ...
Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University ...
Structural and kinetic analyses of holothurian sulfated glycans suggest potential treatment for SARS-CoV-2 infection
Rohini Dwivedi 1, Priyanka Samanta 1, Poon...
Potential Anti-SARS-CoV-2 Activity of Pentosan Polysulfate and Mucopolysaccharide Polysulfate
Fuming Zhang1,*, Peng He2, Andre L. Rodrigues1, Walter Jeske<...
GRASP depletion-mediated Golgi fragmentation impairs glycosaminoglycan synthesis, sulfation, and secretion
Erpan Ahat, Yuefan Song, Ke Xia, Whitney Reid, Jie Li, Sarah Bui, Fuming Z...
Department of Molecular, Cellular and Developmental Biology, University of Michigan, 1105 Nort...
Marine sulfated glycans inhibit the interaction of heparin with S-protein of SARS-CoV-2 Omicron XBB variant
Peng He1,2 · Yuefan Song1,3 · Weihua Jin1,4 &middo...
1 Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Tr...
Polymer characterization by size-exclusion chromatography with multi-angle light scattering (SEC-MALS): a tutorial review
John B. Matsona, Anna Q. Steelea , Jonathan D. Ma...
a Virginia Tech, Department of Chemistry and Macromolecules Innovation Institu...
Sulfated Glycans Inhibit the Interaction of MERS-CoV Receptor Binding Domain with Heparin
Jiyuan Yang1,2,Yuefan Song2,Weihua Jin3,Ke Xia 2
1 The Key Laboratory of Molecular Microbiology and Technology, Ministry of Edu...
Quality control, safety assessment and preparation approaches of low molecular weight heparin
Yanlei Yu a 1, Yue Song a ...
a College of Pharmaceutical Science & Collaborative Innovation Center for ...
Polysaccharide Aldehydes and Ketones: Synthesis and Reactivity
Zhenghao Zhai1, Kevin J. Edgar2
1,2. Macromolecules Innovation Institute, Virginia Tech, Blacksburg, Virginia 24061, United St...
Chemobiocatalytic Synthesis of a Low-Molecular-Weight Heparin
Yanlei Yu, Li Fu, Peng He, Ke Xia, Sony Varghese, Hong Wang, Fuming Zhang*, J...
College of Pharmaceutical Science & Collaborative Innovation Center for Yangtze River Delt...
Anti-SARS-CoV-2 Activity of Rhamnan Sulfate from Monostroma nitidum
Song, Yuefan, Peng He, Andre L. Rodrigues, Payel Datta, Ritesh Tandon, John T. Bates, Michael ...
Departments of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary ...
Kinetics of Calcite Nucleation onto Sulfated Chitosan Derivatives and Implications for Water−Polysaccharide Interactions during Crystallization of Sparingly Soluble Salts
Brenna M. Knight, Ronnie Mondal, Nizhou Han, Nicholas F. Pietra, Brady A. Hall, Kevin J. Edgar...
1. Department of Chemistry, Department of Geosciences, Macromolecules Innovation Institute, an...
Ethyl cellulose-block-poly(benzyl glutamate) block copolymer compatibilizers for ethyl cellulose/poly(ethylene terephthalate) blends
Abigail F. Chinn, Isabela Trindade Coutinho, Saipranavi Reddy Kethireddy, Noah R. Williams, Ro...
Department of Chemistry, Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, V...
Identification of a family of peptidoglycan transpeptidases reveals that Clostridioides difficile requires noncanonical cross-links for viability
Kevin W Bollinger 1, Ute Müh 1 , Karl L Ocius...
1 Department of Microbiology and Immunology, Carver College of Medicine, University...
Sonchus asper (L.) Hill extracts: phytochemical characterization and exploitation of its biological activities by loading into nanovesicles
Valentina Parisi, Valentina Santoro, Immacolata Faraone, Nadia Benedetto, Antonio Vassallo, , ...
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084 Salerno, Italy...
Kinetic and Structural Aspects of Glycosaminoglycan–Monkeypox Virus Protein A29 Interactions Using Surface Plasmon Resonance
Deling Shi1,2,Peng He2, Yuefan Song2, Shuihong Cheng2
1National Glycoengineering Research Center, Shandong University, Qingdao 266237, Ch...
Systematic synthesis of bisected N-glycans and unique recognitions by glycan-binding proteins
Xuefeng Cao,‡ Shuaishuai Wang,‡ Madhusudhan Redd...
Department of Chemistry, Georgia State University, Atlanta, GA, USA
MU Center for Re...
Investigation of the pharmacokinetic properties of synthetic heparan sulfate oligosaccharides
Katelyn Arnold, Zhangjie Wang, Andrew Lucas, William Zamboni, Yongmei Xu,&...
Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, Univer...
Increased 3-O-sulfated heparan sulfate in Alzheimer’s disease brain is associated with genetic risk gene HS3ST1
Zhangjie Wang, Vaishali N. Patel, Xuehong Song, Yongmei Xu, Andrea M. Kaminski, Vivien Uyen Do...
Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University ...
Synthesis of bottlebrush polymers based on poly( N -sulfonyl aziridine) macromonomers
William R. Archer, Grace E. Dinges, Piper L. MacNicol and Michael D. Schulz&nbs...
Department of Chemistry and Macromolecules Innovation Institute, Virginia Tech, Blacksburg, VA...
Characterizing Ion-Polymer Interactions in Aqueous Environment with Electric Fields
Valerie Vaissier Welborn*, William R. Archer, and Michael D. S...
Department of Chemistry, Macromolecules Innovation Institute (MII), Virginia Tech, Blacksburg,...
Activities of Family 18 Chitinases on Amorphous Regenerated Chitin Thin Films and Dissolved Chitin Oligosaccharides: Comparison with Family 19 Chitinases
Guoqiang Yu, Gehui Liu, Tianyi Liu, Ethan H. Fink, and Alan R. Esker<...
Department of Chemistry, Virginia Tech, Blacksburg, Virginia24061, United States
Macromo...
Influence of the Norbornene Anchor Group in Ru-Mediated Ring-Opening Metathesis Polymerization: Synthesis of Linear Polymers
Samantha J. Scannelli, Anshul Paripati, Jeffrey R. Weaver, Clark Vu, Mohammed A...
Department of Chemistry, Virginia Tech, Blacksburg, Virginia 24061, United States
Ma...
SPR Sensor-Based Analysis of the Inhibition of Marine Sulfated Glycans on Interactions between Monkeypox Virus Proteins and Glycosaminoglycans
Peng He1,2, Deling Shi1,2, Yunran Li1,3, Ke Xia1,2...
1Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Ins...
The Sea Cucumber Thyonella gemmata Contains a Low Anticoagulant Sulfated Fucan with High Anti-SARS-CoV-2 Actions against Wild-Type and Delta Variants
Rohini Dwivedi, Marwa Farrag, Poonam Sharma, Deling Shi, Anter A. Shami,&...
Department of BioMolecular Sciences, University of Mississippi, Oxford, Mississippi 38677, Uni...
Fibrolamellar Carcinomas–Growth arrested by paracrine signals complexed with synthesized 3-O sulfated heparan sulfate oligosaccharides
Wencheng Zhang a b c d Yo...
aDepartment of Cell Biology and Physiology, University of North Carolina, Chapel Hi...
Regional and disease-specific glycosaminoglycan composition and function in decellularized human lung extracellular matrix
Evan Hoffman a, Yuefan Song b, Fuming ...
aLarner College of Medicine, University of Vermont, 149 Beaumont Avenue, Health Sci...
Site specific N- and O-glycosylation mapping of the spike proteins of SARS-CoV-2 variants of concern
Asif Shajahan, Lauren E. Pepi, Bhoj Kumar, Nathan B. Murray & Par...
Vaccine Production Program, Vaccine Research Center, National Institutes of Health, 9 W Watkin...
Peculiar Phosphonate Modifications of Velvet Worm Slime Revealed by Advanced Nuclear Magnetic Resonance and Mass Spectrometry
Alexandre Poulhazan, Alexander Baer, Gagan Daliaho, Frederic Mentink-Vigier,&nb...
Department of Chemistry, Université du Québec à Montréal, Montreal...
Automated Characterization of Macroscale Tissue 3D Spatial Material Properties via Robotically-Directed Impedimetric Sensing
Ezgi Kucukdeger , Yujing Zhang, Junru Zhang, Yang Liu, Xiaoting Jia , and Blake N. Johnson
Grado Department of Industrial and Systems Engineering, Virginia Tech, Blacksburg, VA 24061 US...
Chitosan as a Canvas for Studies of Macromolecular Controls on CaCO3 Biological Crystallization
Brenna M. Knight, Kevin J. Edgar, James J. De Yoreo, and Patricia M. Dove<...
Department of Chemistry, Virginia Tech, Blacksburg, Virginia 24061, United States
Ma...
Lectin Fingerprinting Distinguishes Antibody Neutralization in SARS-CoV‑2
Michael G. Wuo, Amanda E. Dugan, Melanie Halim, Blake M. Hauser, Jared Feldman,...
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139...
Synthesis of multivalent sialyllactose-conjugated PAMAM dendrimers: Binding to SARS-CoV-2 spike protein and influenza hemagglutinin
Peng He a b, Ke Xia a a Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institu...
Control of tissue homeostasis by the extracellular matrix: Synthetic heparan sulfate as a promising therapeutic for periodontal health and bone regeneration
P. A. Miguez, E. Bash, M. L. Musskopf, S. A. Tuin, A. Rivera-Concepcion,&n...
Division of Comprehensive Oral Health - Periodontology, Adams School of Dentistry, University ...
Fundamentals of Hybrid Cellulose Nanofibril Foam Production by Microwave-Assisted Thawing/Drying Mechanism
Md Musfiqur Rahman, Islam Hafez*, Mehdi Tajvidi, and Aria...
Laboratory of Renewable Nanomaterials, School of Forest Resources, University of Maine, 5755 N...
Steger Hall, Fralin Life Sciences Institute, Virginia Tech
1015 Life Science Cir, Blacksburg, VA 24061