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Glycomaterials Chronicles

Explore curated research chronicles, originating experimental data, spectral analysis, and related open-access publications across carbohydrate materials research.

Open Access publications hosted on VTechWorks
In-House Research
<p>Fibrolamellar Carcinomas&ndash;Growth arrested by paracrine signals complexed with synthesized 3-O sulfated heparan sulfate oligosaccharides</p>

Fibrolamellar Carcinomas–Growth arrested by paracrine signals complexed with synthesized 3-O sulfated heparan sulfate oligosaccharides

Wencheng Zhang a b c d 1, Yongmei Xu e f 1 2, Xicheng Wang b c d 3, Tsunekazu Oi...

aDepartment of Cell Biology and Physiology, University of North Carolina, Chapel...

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In-House Research
<p>New insights into the binding of PF4 to long heparin oligosaccharides in ultralarge complexes using mass spectrometry</p>

New insights into the binding of PF4 to long heparin oligosaccharides in ultralarge complexes using mass spectrometry

Deling Shi 1 2, Huimin Zhao 1, Changkai Bu 1, Keith Fraser 2 3, Haoran Wang 1, J...

1National Glycoengineering Research Center, Shandong University, Qingdao, Shando...

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In-House Research
<p>Seaweed-derived fucoidans and rhamnan sulfates serve as potent anti-SARS-CoV-2 agents with potential for prophylaxis</p>

Seaweed-derived fucoidans and rhamnan sulfates serve as potent anti-SARS-CoV-2 agents with potential for prophylaxis

Yuefan Song a, Amit Singh b, Maisha M. Feroz a c, Shirley Xu a c, Fuming Zhang a...

a Center for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic I...

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In-House Research
<p>Heparin Specifically Inhibits CRISPR/Cas12 Activation, Enabling Ultrasensitive Heparin Detection and Gene Editing Regulation</p>

Heparin Specifically Inhibits CRISPR/Cas12 Activation, Enabling Ultrasensitive Heparin Detection and Gene Editing Regulation

Min Cao, Xinlan Bian, Zhirun Ji, Muhammad Sohail, Fuming Zhang, Robert J. Linhar...

Min Cao − School of Food Science and PharmaceuticalEngineering, Nanjing Normal U...

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In-House Research
<p>Developing a solid-phase method for the enzymatic synthesis of heparan sulfate and chondroitin sulfate backbones</p>

Developing a solid-phase method for the enzymatic synthesis of heparan sulfate and chondroitin sulfate backbones

Stancanelli, Eduardo; Liu, Wei; Su, Guowei; Padagala, Vijay; Liu, Jian

  • 1Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pha...
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In-House Research
<p>Absolute pharmacokinetics of heparin in primates</p>

Absolute pharmacokinetics of heparin in primates

Yuefan Song a, Ahmed Kouta b, Lee M. Cera c, Ke Xia a, Fuming Zhang a, Roland Kr...

aCenter for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic ...

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In-House Research
<p>Dynamic Changes in Heparan Sulfate Nanostructure in Human Pluripotent Stem Cell Differentiation</p>

Dynamic Changes in Heparan Sulfate Nanostructure in Human Pluripotent Stem Cell Differentiation

Mahbuba, Deena Al; Masuko, Sayaka; Wang, Shiwei; Syangtan, Deepsing; Kang, Jeong...

Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts...

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In-House Research
<p>Sulfated Glycans Inhibit the Interaction of MERS-CoV Receptor Binding Domain with Heparin</p>

Sulfated Glycans Inhibit the Interaction of MERS-CoV Receptor Binding Domain with Heparin

J. Yang; Y. Song; W. Jin; K. Xia; G. C. Burnett; W. Qiao; J. T. Bates; V. H. Pom...

1The Key Laboratory of Molecular Microbiology and Technology, Ministry of Educat...

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In-House Research
<p>Inhibition of sulfated glycans on the binding of dengue virus envelope protein to heparin</p>

Inhibition of sulfated glycans on the binding of dengue virus envelope protein to heparin

Jiyuan Yang, Payel Datta, Ke Xia, Vitor H. Pomin, Chunyu Wang, Mingqiang Qiao, R...

Departments of Chemical and Biological Engineering, Rensselaer Polytechnic Insti...

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In-House Research
<p>Characterization of heparin interactions with Clostridioides difficile toxins and its potential as anti-CDI therapeutics</p>

Characterization of heparin interactions with Clostridioides difficile toxins and its potential as anti-CDI therapeutics

Fuming Zhang, Shaohui Wang, Jiyuan Yang, Keith Fraser, James M. Gibson, Chunyu W...

Department of Chemical and Biological Engineering, Center for Biotechnology and ...

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In-House Research
<p>Thermodynamics of calcium binding to heparin: Implications of solvation and water structuring for polysaccharide biofunctions</p>

Thermodynamics of calcium binding to heparin: Implications of solvation and water structuring for polysaccharide biofunctions

Brenna M. Knight,  Connor M. B. Gallagher, Michael D. Schulz, Kevin J. Edgar, Ca...

Department of Chemistry, Virginia Tech, Blacksburg, VA 24061
Macromolecules Inn...
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In-House Research
<p>Structural Characteristics of Heparin Binding to SARS-CoV-2 Spike Protein RBD of Omicron Sub-Lineages BA.2.12.1, BA.4 and BA.5</p>

Structural Characteristics of Heparin Binding to SARS-CoV-2 Spike Protein RBD of Omicron Sub-Lineages BA.2.12.1, BA.4 and BA.5

Deling Shi1,2, Changkai Bu1, Peng He2, Yuefan Song2, Jonathan S. Dordick2, Rober...

1National Glycoengineering Research Center, Shandong University, Qingdao 266237,...

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In-House Research
<p>The diverse role of heparan sulfate and other GAGs in SARS-CoV-2 infections and therapeutics</p>

The diverse role of heparan sulfate and other GAGs in SARS-CoV-2 infections and therapeutics

Friederike Eilts a b 1, Sarah Bauer a 1, Keith Fraser c 1, Jonathan S. Dordick a...

aDepartment of Chemical and Biological Engineering, Center for Biotechnology and...

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In-House Research
<p>Soluble &alpha;-klotho and heparin modulate the pathologic cardiac actions of fibroblast growth factor 23 in chronic kidney disease</p>

Soluble α-klotho and heparin modulate the pathologic cardiac actions of fibroblast growth factor 23 in chronic kidney disease

Christopher Yanucil 1, Dominik Kentrup 1 2, Isaac Campos 1, Brian Czaya 1, Kylie...

1Division of Nephrology, Department of Medicine, The University of Alabama at Bi...

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In-House Research
<p>Ionically Complexed Nanoparticles for Heparin Oral Delivery</p>

Ionically Complexed Nanoparticles for Heparin Oral Delivery

Bhagyashree Subramaniam, Nicole Leonick, Varenya Gade, David M. Frey, Fuming Zha...

Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, ...

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In-House Research
<p>Interactions of marine sulfated glycans with antithrombin and platelet factor 4</p>

Interactions of marine sulfated glycans with antithrombin and platelet factor 4

Wenjing Zhang, Weihua Jin, Vitor Hugo Pomin, Fuming Zhang, Robert J. Linhardt

1Department of Endocrinology, Sir Run Run Shaw Hospital, Zhejiang University Sch...

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In-House Research
<p>Interactions between heparin and SARS-CoV-2 spike glycoprotein RBD from omicron and other variants</p>

Interactions between heparin and SARS-CoV-2 spike glycoprotein RBD from omicron and other variants

Gelbach, Adrianne L., Fuming Zhang, Seok-Joon Kwon, John T. Bates, Andrew P. Far...

1Department of Biological Sciences, Center for Biotechnology and Interdisciplina...

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In-House Research
<p>Fractionation of sulfated galactan from the red alga&nbsp;<em>Botryocladia occidentalis</em>&nbsp;separates its anticoagulant and anti-SARS-CoV-2 properties</p>

Fractionation of sulfated galactan from the red alga Botryocladia occidentalis separates its anticoagulant and anti-SARS-CoV-2 properties

Seon Beom Kim 1, Mary Zoepfl 2, Priyanka Samanta 1, Fuming Zhang 3, Ke Xia 3, Re...

  1. Department of BioMolecular Sciences, University of Mississippi, University, M...
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In-House Research
<p>Enzymatic synthesis of low molecular weight heparins from&nbsp;<em>N</em>-sulfo heparosan depolymerized by heparanase or heparin lyase</p>

Enzymatic synthesis of low molecular weight heparins from N-sulfo heparosan depolymerized by heparanase or heparin lyase

Yanlei Yu a, Li Fu b e, Peng He b, Ke Xia b, Sony Varghese e, Jonathan Dordick c...

College of Pharmaceutical Science & Collaborative Innovation Center for Yangtze ...

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In-House Research
<p>Anti-SARS-CoV-2 and anticoagulant properties of&nbsp;<em>Pentacta pygmaea</em>&nbsp;fucosylated chondroitin sulfate depend on high molecular weight structures</p>

Anti-SARS-CoV-2 and anticoagulant properties of Pentacta pygmaea fucosylated chondroitin sulfate depend on high molecular weight structures

Rohini Dwivedi, Poonam Sharma, Friederike Eilts, Fuming Zhang, Robert J Linhardt...

Department of BioMolecular Sciences, University of Mississippi, Oxford, Mississi...

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