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Glycomaterials Chronicles

Explore curated research chronicles, originating experimental data, spectral analysis, and related open-access publications across carbohydrate materials research.

Open Access publications hosted on VTechWorks
In-House Research
<p>Marine-derived sulfated glycans display a potent virostatic mechanism to block herpes simplex virus type-1 (HSV-1) entry and spread</p>

Marine-derived sulfated glycans display a potent virostatic mechanism to block herpes simplex virus type-1 (HSV-1) entry and spread

James Elste, Michele Rabbitt, Chunyu Wang, Jonathan S. Dordick, Vaibhav Tiwari, ...

Department of Microbiology & Immunology, College of Graduate Studies, Midwestern...

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In-House Research
<p>Characterization of heparin interactions with Clostridioides difficile toxins and its potential as anti-CDI therapeutics</p>

Characterization of heparin interactions with Clostridioides difficile toxins and its potential as anti-CDI therapeutics

Fuming Zhang, Shaohui Wang, Jiyuan Yang, Keith Fraser, James M. Gibson, Chunyu W...

Department of Chemical and Biological Engineering, Center for Biotechnology and ...

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In-House Research
<p>Thermodynamics of calcium binding to heparin: Implications of solvation and water structuring for polysaccharide biofunctions</p>

Thermodynamics of calcium binding to heparin: Implications of solvation and water structuring for polysaccharide biofunctions

Brenna M. Knight,  Connor M. B. Gallagher, Michael D. Schulz, Kevin J. Edgar, Ca...

Department of Chemistry, Virginia Tech, Blacksburg, VA 24061
Macromolecules Inn...
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In-House Research
Open Access
<p>Effects of Copper on&nbsp;Legionella pneumophila&nbsp;Revealed via Viability Assays and Proteomics</p>

Effects of Copper on Legionella pneumophila Revealed via Viability Assays and Proteomics

Yang Song 1,2,*, Didier Mena-Aguilar 3,4, Connor L. Brown 5, William J. Rhoads 1...

1Civil and Environmental Engineering, Virginia Tech, 1145 Perry St., 418 Durham ...

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In-House Research
<p>Discovery of Novel Effector Protein Candidates Produced in the Dorsal Gland of Root-Knot Nematode Adult Females</p>

Discovery of Novel Effector Protein Candidates Produced in the Dorsal Gland of Root-Knot Nematode Adult Females

Rocha, Raquel; Hussey, Richard; Pepi, Lauren; Azadi, Parastoo; Mitchum, Melissa

1Department of Plant Pathology and Institute of Plant Breeding, Genetics, and Ge...

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In-House Research
<p>Editorial: In celebration of women in science: glycoscience</p>

Editorial: In celebration of women in science: glycoscience

Roman, Maren1; Chandran, Preethi L.2,3; Haurat, M. Florencia4

  • 1Virginia Tech, Blacksburg, VA, United States
  • 2Department of Biochemistry a...
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In-House Research
<p>Structural Characteristics of Heparin Binding to SARS-CoV-2 Spike Protein RBD of Omicron Sub-Lineages BA.2.12.1, BA.4 and BA.5</p>

Structural Characteristics of Heparin Binding to SARS-CoV-2 Spike Protein RBD of Omicron Sub-Lineages BA.2.12.1, BA.4 and BA.5

Deling Shi1,2, Changkai Bu1, Peng He2, Yuefan Song2, Jonathan S. Dordick2, Rober...

1National Glycoengineering Research Center, Shandong University, Qingdao 266237,...

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In-House Research
<p>Chemoenzymatic synthesis of sulfur-linked sugar polymers as heparanase inhibitors</p>

Chemoenzymatic synthesis of sulfur-linked sugar polymers as heparanase inhibitors

Peng He, Xing Zhang, Ke Xia, Dixy E. Green, Sultan Baytas, Yongmei Xu, Truong Ph...

Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic I...

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In-House Research
<p>Soluble &alpha;-klotho and heparin modulate the pathologic cardiac actions of fibroblast growth factor 23 in chronic kidney disease</p>

Soluble α-klotho and heparin modulate the pathologic cardiac actions of fibroblast growth factor 23 in chronic kidney disease

Christopher Yanucil 1, Dominik Kentrup 1 2, Isaac Campos 1, Brian Czaya 1, Kylie...

1Division of Nephrology, Department of Medicine, The University of Alabama at Bi...

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In-House Research
<p>Interactions between heparin and SARS-CoV-2 spike glycoprotein RBD from omicron and other variants</p>

Interactions between heparin and SARS-CoV-2 spike glycoprotein RBD from omicron and other variants

Gelbach, Adrianne L., Fuming Zhang, Seok-Joon Kwon, John T. Bates, Andrew P. Far...

1Department of Biological Sciences, Center for Biotechnology and Interdisciplina...

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In-House Research
<p>Fractionation of sulfated galactan from the red alga&nbsp;<em>Botryocladia occidentalis</em>&nbsp;separates its anticoagulant and anti-SARS-CoV-2 properties</p>

Fractionation of sulfated galactan from the red alga Botryocladia occidentalis separates its anticoagulant and anti-SARS-CoV-2 properties

Seon Beom Kim 1, Mary Zoepfl 2, Priyanka Samanta 1, Fuming Zhang 3, Ke Xia 3, Re...

  1. Department of BioMolecular Sciences, University of Mississippi, University, M...
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In-House Research
<p>Computationally guided conversion of the specificity of E-selectin to mimic that of Siglec-8</p>

Computationally guided conversion of the specificity of E-selectin to mimic that of Siglec-8

Xiaocong Wang, Melinda S. Hanes, Richard D. Cummings, and Robert J. Woods 

Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Hua...

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In-House Research
<p>Cholesterol Chip for the Study of Cholesterol&ndash;Protein Interactions Using SPR</p>

Cholesterol Chip for the Study of Cholesterol–Protein Interactions Using SPR

Peng He1,2,†, Shannon Faris1,2,†, Reddy Sudheer Sagabala3, Payel Datta1,2, Zihan...

  1. Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institut...
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In-House Research
<p>Anti-SARS-CoV-2 and anticoagulant properties of&nbsp;<em>Pentacta pygmaea</em>&nbsp;fucosylated chondroitin sulfate depend on high molecular weight structures</p>

Anti-SARS-CoV-2 and anticoagulant properties of Pentacta pygmaea fucosylated chondroitin sulfate depend on high molecular weight structures

Rohini Dwivedi, Poonam Sharma, Friederike Eilts, Fuming Zhang, Robert J Linhardt...

Department of BioMolecular Sciences, University of Mississippi, Oxford, Mississi...

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In-House Research
<p>A Cluster Sequencing Strategy To Determine the Consensus Affinity Domains in Heparin for Its Binding to Specific Proteins</p>

A Cluster Sequencing Strategy To Determine the Consensus Affinity Domains in Heparin for Its Binding to Specific Proteins

Deling Shi, Anran Sheng, Changkai Bu, Zizhe An, Xueying Cui, Xiaojun Sun, Hongme...

National Glycoengineering Research Center, Shandong University, Qingdao, Shandon...

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In-House Research
<p>Chemoenzymatic Synthesis of Homogeneous Heparan Sulfate and Chondroitin Sulfate Chimeras</p>

Chemoenzymatic Synthesis of Homogeneous Heparan Sulfate and Chondroitin Sulfate Chimeras

Eduardo Stancanelli, Wei Liu, Rylee Wander, Jine Li, Zhangjie Wang, Katelyn Arno...

Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmac...

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In-House Research
<p>Structural and Substrate Specificity Analysis of 3-<em>O</em>-Sulfotransferase Isoform 5 to Synthesize Heparan Sulfate</p>

Structural and Substrate Specificity Analysis of 3-O-Sulfotransferase Isoform 5 to Synthesize Heparan Sulfate

Rylee Wander, Andrea M. Kaminski, Zhangjie Wang, Eduardo Stancanelli, Yongmei Xu...

Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmac...

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In-House Research
<p>Structural and kinetic analyses of holothurian sulfated glycans suggest potential treatment for SARS-CoV-2 infection</p>

Structural and kinetic analyses of holothurian sulfated glycans suggest potential treatment for SARS-CoV-2 infection

Rohini Dwivedi 1, Priyanka Samanta 1, Poonam Sharma 2, Fuming Zhang 3, Sushil K....

  1. Department of BioMolecular Sciences, University of Mississippi, Oxford, Missi...
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In-House Research
<p>Potential Anti-SARS-CoV-2 Activity of Pentosan Polysulfate and Mucopolysaccharide Polysulfate</p>

Potential Anti-SARS-CoV-2 Activity of Pentosan Polysulfate and Mucopolysaccharide Polysulfate

Fuming Zhang1,*, Peng He2, Andre L. Rodrigues1, Walter Jeske3, Ritesh Tandon4,5,...

  1. Department of Chemical and Biological Engineering, Center for Biotechnology a...
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In-House Research
<p>Marine sulfated glycans inhibit the interaction of heparin with S-protein of SARS-CoV-2 Omicron XBB variant</p>

Marine sulfated glycans inhibit the interaction of heparin with S-protein of SARS-CoV-2 Omicron XBB variant

Peng He1,2 · Yuefan Song1,3 · Weihua Jin1,4 · Yunran Li1,3 · Ke Xia1,3 · Seon Be...

1 Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic...

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