Fucosylated chondroitin sulfate


Background Pentacta pygmaea (PpFucCS) was extracted from sea cucumber and it's structure was analyzed using NMR.PpFucCS exhibits strong binding to S-protein RBD compared to heparin.
Type Glycosaminoglycans
Source Pentacta pygmaea(Sea cucumber)
Weight 10-60 kDa
Backbone/Unit {→3)-β-GalNAcX-(1→4)-β-GlcA-[(3→1)Y]-(1→} where X = 4S(80%), 6S(10%) or nonsulfated(10%), Y = αFuc2,4S (40%), α-Fuc2,4S-(1→4)-α-Fuc(30%)
Structure

Properties

IC50 calculations for SARS-CoV-2: 0.0279 mg/l


Spectra

NMR