POSITION SPECIFICS​

The Penn State College of Medicine, Proteomics Mass Spectrometry Biomedical Core Facility is seeking a highly qualified Manager with expertise in Proteomics to lead and advance the Mass Spec & Proteomics Core. The successful candidate will be instrumental in delivering high-throughput proteomic services to support a wide range of research initiatives across the institution. This role encompasses executing complex proteomic workflows, ensuring optimal performance of advanced instrumentation, and managing efficient day-to-day laboratory operations. Strong knowledge of proteomics workflows, sample preparation, and qualitative and quantitative analysis is required and excellent organizational, communication, and problem-solving skills are required

This is an on-site, in-person position in Hershey, PA.

Key responsibilities include, but are not limited to

• Perform mass spectrometric analyses for identification and quantitation of proteins, peptides, oligonucleotides, carbohydrates, and lipids, including sample preparation, extraction, and quality control following established protocols.

• Conduct advanced proteomics data analysis, including peptide/protein identification, quantitative workflows (label-based and label-free), PTM analysis, and bioinformatics interpretation using tools such as Byonic, DIANA, MSFragger, and Scaffold.

• Operate and maintain mass spectrometry instruments (TimsTOF Flex, QuickPlex SQ120, etc.) to ensure optimal performance and uptime.

• Ensure data accuracy and integrity through rigorous quality control (QC) and quality assurance (QA) procedures.

• Maintain detailed and organized records of all experimental procedures, results, and quality metrics.

• Provide exceptional customer service by communicating effectively with researchers, addressing inquiries, and ensuring timely delivery of high-quality analytical results.

• Collaborate with investigators and colleagues to support diverse research projects and foster a team-oriented environment.

• Troubleshoot assays and instrumentation to maintain efficient and reliable laboratory operations.

• Stay current with advancements in mass spectrometry technologies and recommend improvements to workflows and instrumentation.

• Train students and researchers on instrument operation, best practices, and data interpretation as needed.

Preferred Qualifications

• Master’s in Biochemistry, Molecular biology, Chemistry, Analytical Science, or related field or equivalent experience required. PhD preferred.

• Minimum 3–5 years of hands-on experience with mass spectrometry techniques and data interpretation required. Experience scripting in R or Python would be preferable.

MINIMUM EDUCATION, WORK EXPERIENCE & REQUIRED CERTIFICATIONS

Master's Degree 3+ years of relevant experience; or an equivalent combination of education and experience accepted Required Certifications: None

BACKGROUND CHECKS/CLEARANCES

Employment with the University will require successful completion of background check(s) in accordance with University policies.

Penn State does not sponsor or take over sponsorship of a staff employment Visa. Applicants must be authorized to work in the U.S.

SALARY & BENEFITS

The salary range for this position, including all possible grades, is $68,200.00 - $102,300.00.