Polymer–Carbohydrate Conjugates
Table: Polymer–carbohydrate conjugates and the nanostructures they self-assemble into. Each entry records which synthetic polymer is paired with which carbohydrate, whether the result was characterized by experiment or simulation, the self-assembled shape (micelle, vesicle/polymersome, nanoparticle, worm-like micelle, lamellae, hydrogel, …) and its size. Expand Conditions / Comments for measurement details and the supporting quote. Click any column header to sort.
| # | Conjugate | Polymer | Carbohydrate | Method | Shape | Size | Conditions | Ref (DOI) | Comments |
|---|---|---|---|---|---|---|---|---|---|
| 1 | PDMAEMA-b-PMAIGP galactose glycopolymer | poly(2-dimethylaminoethyl methacrylate) (PDMAEMA) | galactose (MAIGP) | Experiment | spheres, worms, lamellae, multilayer lamellae, complex vesicles | ~40 nm to ~1.0 um (DLS/TEM/cryo-TEM/SEM) |
RAFT dispersion polymerization, 5-20% solidshighly ordered glyco-inside nano-assemblies; morphology controlled by PMAIGP DP and solids content
|
10.1002/anie.202015692 |
Viewa series of highly ordered glyco-inside nano-assemblies (spheres, worms, lamellae, multilayer lamellae and complex vesicles) were fabricated. (confidence: high) |
| 2 | PEGylated ethyl cellulose (EC-PEG) | poly(ethylene glycol) (PEG) | ethyl cellulose | Experiment | micelle | ~80 nm (blank); 153.5-350.5 nm loaded |
aqueous, DLS+TEM+CMCEC-PEG amphiphile self-assembles into nano-micelles; DOX loading increased size; CMC by pyrene fluorescence
|
10.1039/D1RA04242D |
Viewthe average size of the nano-micelles was recorded to be ~80 nm. (confidence: high) |
| 3 | PLA-b-(PTA-g-mannose) | poly(lactic acid)/polyester (OCA-based) | mannose | Experiment | spherical micelle | hydrodynamic diameter 80-130 nm (DLS/TEM) |
aqueous, DLS+TEMbiodegradable micelle for mannose-mediated targeted drug delivery; size grows with mannose block length
|
10.1002/marc.201400650 |
ViewThe micelles possessed hydrodynamic diameters of 80-130 nm; increasing the hydrophilic PTA-g-mannose block length increased particle size. (confidence: high) |
| 4 | acetyl-modified chitosan hydrogel | acetyl modification | chitosan | Simulation | uniform homogeneous network | pores 1.0-1.5 nm; end-to-end 14.4 nm |
multiscale coarse-grained MD, aqueousMultiscale coarse-grained (force-matching) MD; reference GLYCAM06/TIP5P; uniform network
|
10.1039/D0SM01243B |
ViewAcetyl-chitosan forms uniform networks where chains remain evenly distributed throughout the simulation box. (confidence: high) |
| 5 | alkyl glucoside GLUCO12 | C12 alkyl chain | glucose (glucoside) | Simulation | elongated/oblate micelle | Nagg 252 (GLUCO12); CMC 1.87 mM (GLUCO10) |
DPD, aqueousDissipative particle dynamics; parameters from molecular mechanics and B3LYP/6-31G*
|
10.1021/acs.jpcb.1c00480 |
ViewGLUCO systems show elongated micelles with an oblate form. (confidence: high) |