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{
"count": 25,
"next": "http://glycodata.org/api/gdd/polymer-carbohydrate-conjugates/?format=api&page=2",
"previous": null,
"results": [
{
"id": 1,
"conjugate": "dextran-g-oleylamine (Dex-g-OA)",
"polymer": "oleylamine (hydrophobic graft)",
"carbohydrate": "dextran (T40, Mw 40000)",
"method": "Experiment",
"shape": "spherical micelle",
"size": "mean diameter 338.1 nm (THF/H2O), 549.7 nm (CH2Cl2/H2O) by DLS",
"conditions": "aqueous (THF/H2O or CH2Cl2/H2O), DLS+SEM",
"conditions_detail": "amphiphilic dextran formed via Schiff base reaction between oxidized dextran and oleylamine; self-assembled into spherical nanoparticles",
"doi": "10.1093/rb/rbac096",
"comments": "DLS measurements showed that the mean diameters of the Dex-g-OA micelles were 338.1 and 549.7 nm, respectively. (confidence: high)"
},
{
"id": 2,
"conjugate": "dextran-b-PLGA (DexbLG)",
"polymer": "poly(DL-lactide-co-glycolide) (PLGA)",
"carbohydrate": "dextran (Mw ~6000)",
"method": "Experiment",
"shape": "spherical core-shell micelle",
"size": "~70-80 nm (empty); 122-206 nm drug-loaded (DLS/TEM)",
"conditions": "aqueous, dialysis, DLS+TEM",
"conditions_detail": "PLGA hydrophobic core, dextran hydrophilic shell; doxorubicin-loaded micelles grew with drug content",
"doi": "10.2147/IJN.S19491",
"comments": "DexbLG block copolymer formed polymeric micelles with a narrow size distribution; TEM shows micelles smaller than 100 nm. (confidence: high)"
},
{
"id": 3,
"conjugate": "hyaluronic acid-g-PLGA (HAgLG)",
"polymer": "poly(DL-lactide-co-glycolide) (PLGA)",
"carbohydrate": "hyaluronic acid",
"method": "Experiment",
"shape": "spherical core-shell micelle",
"size": "~81 nm, <100 nm (DLS/TEM)",
"conditions": "aqueous, dialysis, DLS+TEM",
"conditions_detail": "HA hydrated outer shell, PLGA hydrophobic inner core; for tumor targeting",
"doi": "10.3390/ijms150916057",
"comments": "Polymeric micelles of HAgLG have small particle sizes less than 100 nm and are spherical in shape. (confidence: high)"
},
{
"id": 4,
"conjugate": "hyaluronan-ferulic acid-HEG-oleic acid (HA-FA-HEG-OA)",
"polymer": "hexa(ethylene glycol)/oleic acid graft",
"carbohydrate": "hyaluronan",
"method": "Experiment",
"shape": "spherical nanoparticle",
"size": "291 nm empty, 234 nm loaded (DLS)",
"conditions": "aqueous, DLS+TEM",
"conditions_detail": "hyaluronan grafted with ferulic acid via HEG spacers to oleic acid; for olanzapine delivery",
"doi": "10.3390/pharmaceutics11120675",
"comments": "HA-FA-HEG-OA nano-aggregates appeared as spherical objects, slightly smaller by TEM than DLS due to dehydration shrinkage. (confidence: high)"
},
{
"id": 5,
"conjugate": "stearamido-beta-cyclodextrin (S-beta-CD)",
"polymer": "octadecanamido (stearyl amide) chain",
"carbohydrate": "beta-cyclodextrin",
"method": "Experiment",
"shape": "nano-vesicle",
"size": "diameter 53.4 nm (DLS), 24.1 nm (TEM)",
"conditions": "water, DLS+TEM+fluorescence",
"conditions_detail": "amphiphilic fatty amide-beta-CD conjugate self-assembles into nano-vesicles; oleamido analogue 77.8 nm DLS; for retinol stabilization",
"doi": "10.3390/molecules21070963",
"comments": "The self-assembled composites of S-beta-CD show an average diameter of 53.4 nm in the DLS profile; O-beta-CD has a larger mean diameter of 77.8 nm. (confidence: high)"
},
{
"id": 6,
"conjugate": "PEGylated ethyl cellulose (EC-PEG)",
"polymer": "poly(ethylene glycol) (PEG)",
"carbohydrate": "ethyl cellulose",
"method": "Experiment",
"shape": "micelle",
"size": "~80 nm (blank); 153.5-350.5 nm loaded",
"conditions": "aqueous, DLS+TEM+CMC",
"conditions_detail": "EC-PEG amphiphile self-assembles into nano-micelles; DOX loading increased size; CMC by pyrene fluorescence",
"doi": "10.1039/D1RA04242D",
"comments": "the average size of the nano-micelles was recorded to be ~80 nm. (confidence: high)"
},
{
"id": 7,
"conjugate": "PLA-b-(PTA-g-mannose)",
"polymer": "poly(lactic acid)/polyester (OCA-based)",
"carbohydrate": "mannose",
"method": "Experiment",
"shape": "spherical micelle",
"size": "hydrodynamic diameter 80-130 nm (DLS/TEM)",
"conditions": "aqueous, DLS+TEM",
"conditions_detail": "biodegradable micelle for mannose-mediated targeted drug delivery; size grows with mannose block length",
"doi": "10.1002/marc.201400650",
"comments": "The micelles possessed hydrodynamic diameters of 80-130 nm; increasing the hydrophilic PTA-g-mannose block length increased particle size. (confidence: high)"
},
{
"id": 8,
"conjugate": "mannosylated PEG-PCL brush copolymers",
"polymer": "poly(ethylene glycol)-poly(epsilon-caprolactone) (PEG-PCL)",
"carbohydrate": "mannose",
"method": "Experiment",
"shape": "nanoparticle (small spherical aggregate)",
"size": "Dh 7.5-11.3 nm (DLS); 10-20 nm (TEM)",
"conditions": "aqueous and other media, DLS+TEM",
"conditions_detail": "linear and four-arm mannosylated PEG-PCL brush copolymers self-assemble into lectin-binding nanoparticles",
"doi": "10.3762/bjnano.10.212",
"comments": "In any medium, polymers formed nanoparticles with Dh varying from 7.5 to 11.3 nm. (confidence: high)"
},
{
"id": 9,
"conjugate": "galactose diblock copolymer (PGalSMA-PGMA)-PHPMA",
"polymer": "poly(2-hydroxypropyl methacrylate) (PHPMA)/poly(glycerol monomethacrylate) (PGMA)",
"carbohydrate": "galactose (PGalSMA)",
"method": "Experiment",
"shape": "spheres / worm-like micelles / vesicles (tunable)",
"size": "morphology set by PHPMA DP; worms form free-standing gels at 20C",
"conditions": "concentrated aqueous, RAFT PISA, TEM+DLS+rheology",
"conditions_detail": "galactosylated diblock copolymer nano-objects via RAFT PISA; worms form thermo-reversible gels; bind galectins",
"doi": "10.1021/ja407033x",
"comments": "a 9:1 PGMA51/PGalSMA34 ratio allowed synthesis of well-defined spheres, worms, or vesicles depending on the core-block DP. (confidence: high)"
},
{
"id": 10,
"conjugate": "PDMAEMA-b-PMAIGP galactose glycopolymer",
"polymer": "poly(2-dimethylaminoethyl methacrylate) (PDMAEMA)",
"carbohydrate": "galactose (MAIGP)",
"method": "Experiment",
"shape": "spheres, worms, lamellae, multilayer lamellae, complex vesicles",
"size": "~40 nm to ~1.0 um (DLS/TEM/cryo-TEM/SEM)",
"conditions": "RAFT dispersion polymerization, 5-20% solids",
"conditions_detail": "highly ordered glyco-inside nano-assemblies; morphology controlled by PMAIGP DP and solids content",
"doi": "10.1002/anie.202015692",
"comments": "a series of highly ordered glyco-inside nano-assemblies (spheres, worms, lamellae, multilayer lamellae and complex vesicles) were fabricated. (confidence: high)"
},
{
"id": 11,
"conjugate": "beta-D-glucose glycopolymer-PLA hybrid block copolymer",
"polymer": "branched poly(lactic acid) (PLA)",
"carbohydrate": "beta-D-glucose (pendant glycopolymer)",
"method": "Experiment",
"shape": "vesicles (~30% glyco), mixed (~38%), core-shell micelles (~66%)",
"size": "vesicles ~120 nm; core-shell micelles ~41 nm",
"conditions": "aqueous, AFM+TEM+DLS",
"conditions_detail": "hybrid block copolymers of beta-D-glucose glycopolymer and branched PLA via thiol-ene; morphology depends on glyco fraction",
"doi": "10.1021/acs.biomac.4c00885",
"comments": "The Glc 31:69 copolymers self-assemble into spherical bilayer vesicles roughly 120 nm in diameter. (confidence: high)"
},
{
"id": 12,
"conjugate": "glycopolymer-PEG-PLA (Man-/Tre-/G7-PEG-PLA)",
"polymer": "poly(ethylene glycol)-poly(lactic acid) (PEG-PLA)",
"carbohydrate": "mannose, trehalose, maltoheptaose",
"method": "Experiment",
"shape": "micelle (PLA core, carbohydrate surface)",
"size": "~27-31 nm, PDI 0.20-0.28 (DLS)",
"conditions": "aqueous, DLS + ConA binding",
"conditions_detail": "glycopolymer micelles for antibiotic delivery; carbohydrate surface confirmed by Concanavalin A assay",
"doi": "10.3390/molecules28104031",
"comments": "the glycopolymer micelles had a similar size to PEG-PLA around 27-31 nm and PDI 0.20-0.28. (confidence: high)"
},
{
"id": 13,
"conjugate": "octylamine-grafted oxidized sodium alginate (Ugi-OSAOcT)",
"polymer": "octylamine (hydrophobic graft via Ugi reaction)",
"carbohydrate": "sodium alginate (oxidized)",
"method": "Experiment",
"shape": "spherical micelle",
"size": "135.7-196.5 nm (DLS); 90-110 nm (TEM)",
"conditions": "aqueous, DLS+TEM, zeta potential",
"conditions_detail": "amphiphilic biopolymer from oxidized alginate via one-pot Ugi reaction; zeta -32.8 to -38.2 mV",
"doi": "10.3390/polym14040694",
"comments": "All micelles were almost spherical with a size of 90-110 nm and well-dispersed with no aggregation. (confidence: high)"
},
{
"id": 14,
"conjugate": "beta-dodecyl maltoside (beta-C12G2)",
"polymer": "dodecyl (C12 alkyl chain)",
"carbohydrate": "maltose (beta-anomer)",
"method": "Simulation",
"shape": "oblate/ellipsoidal micelle",
"size": "Rg = 25.4 A; aggregation number 132",
"conditions": "all-atom MD, explicit water",
"conditions_detail": "All-atom MD of preformed micelle; CHARMM36-Opt and GLYCAM06 force fields; beta-anomer; Nagg 132",
"doi": "10.1021/jp109545v",
"comments": "The computed radius of gyration is 20.2 A and 25.4 A for the alpha- and beta-anomer micelles, respectively. (confidence: high)"
},
{
"id": 15,
"conjugate": "alpha-dodecyl maltoside (alpha-C12G2)",
"polymer": "dodecyl (C12 alkyl chain)",
"carbohydrate": "maltose (alpha-anomer)",
"method": "Simulation",
"shape": "ellipsoidal micelle",
"size": "Rg = 20.2 A; aggregation number 75",
"conditions": "all-atom MD, explicit water",
"conditions_detail": "All-atom MD; CHARMM36/GLYCAM06; alpha-anomer; semi-axis ratio ~1.20; Nagg 75",
"doi": "10.1021/jp109545v",
"comments": "the alpha-C12G2 micelles have an average major-to-minor semi-axis ratio close to 1.20 whereas the beta-C12G2 micelle has a more pronounced oblate shape. (confidence: high)"
},
{
"id": 16,
"conjugate": "alkyl maltoside MALTO12",
"polymer": "C12 alkyl chain",
"carbohydrate": "maltose",
"method": "Simulation",
"shape": "spherical micelle",
"size": "CMC 0.29 mM (MALTO12); Nagg 19 (MALTO8)",
"conditions": "DPD, aqueous",
"conditions_detail": "Dissipative particle dynamics; parameters from SSIMPLE / B3LYP/6-31G* electrostatic potentials",
"doi": "10.1021/acs.jpcb.1c00480",
"comments": "MALTO12 forms micelles with spherical shapes. (confidence: high)"
},
{
"id": 17,
"conjugate": "alkyl glucoside GLUCO12",
"polymer": "C12 alkyl chain",
"carbohydrate": "glucose (glucoside)",
"method": "Simulation",
"shape": "elongated/oblate micelle",
"size": "Nagg 252 (GLUCO12); CMC 1.87 mM (GLUCO10)",
"conditions": "DPD, aqueous",
"conditions_detail": "Dissipative particle dynamics; parameters from molecular mechanics and B3LYP/6-31G*",
"doi": "10.1021/acs.jpcb.1c00480",
"comments": "GLUCO systems show elongated micelles with an oblate form. (confidence: high)"
},
{
"id": 18,
"conjugate": "mannose amphiphiles (high DP)",
"polymer": "hydrophobic alkyl/lipid tail",
"carbohydrate": "mannose (oligomannose head)",
"method": "Simulation",
"shape": "spherical micelle",
"size": "not reported numerically",
"conditions": "MD in aqueous media",
"conditions_detail": "MD in aqueous media; high degree of polymerization amphiphiles; validated vs DLS, SAXS, cryo-TEM",
"doi": "10.1021/acs.langmuir.2c00579",
"comments": "high-DP amphiphiles self-assemble into spherical micelles irrespective of the hydroxyl group presence; low-DP amphiphiles form cylindrical micelles. (confidence: high)"
},
{
"id": 19,
"conjugate": "mannose amphiphiles (low DP)",
"polymer": "hydrophobic alkyl/lipid tail",
"carbohydrate": "mannose (single hydrophilic moiety)",
"method": "Simulation",
"shape": "cylindrical (rod-like) micelle",
"size": "not reported numerically",
"conditions": "coarse-grained MD, aqueous",
"conditions_detail": "CG MD of self-assembly pathway: clusters -> spherical micelles with sugar shell -> merge/elongate into rods",
"doi": "10.1021/acs.langmuir.2c00579",
"comments": "these spherical micelles merge and lengthen into rod-like micelles. (confidence: high)"
},
{
"id": 20,
"conjugate": "chitosan-citral microcapsule",
"polymer": "citral (essential oil core)",
"carbohydrate": "chitosan (wall material)",
"method": "Simulation",
"shape": "spherical core-shell microcapsule",
"size": "simulation box 200x200x200 A^3; bead radius 2.98 A",
"conditions": "DPD, aqueous",
"conditions_detail": "Dissipative particle dynamics; CG beads, DP 20; three-layer hydrophilic core/shell with hydrophobic medium layer",
"doi": "10.3390/polym17050678",
"comments": "Cts-citral forms a three-layer core-shell with hydrophilic core and shell layers and a hydrophobic medium layer. (confidence: high)"
}
]
}