{"count":25,"next":"http://glycodata.org/api/gdd/polymer-carbohydrate-conjugates/?format=json&page=2","previous":null,"results":[{"id":1,"conjugate":"dextran-g-oleylamine (Dex-g-OA)","polymer":"oleylamine (hydrophobic graft)","carbohydrate":"dextran (T40, Mw 40000)","method":"Experiment","shape":"spherical micelle","size":"mean diameter 338.1 nm (THF/H2O), 549.7 nm (CH2Cl2/H2O) by DLS","conditions":"aqueous (THF/H2O or CH2Cl2/H2O), DLS+SEM","conditions_detail":"amphiphilic dextran formed via Schiff base reaction between oxidized dextran and oleylamine; self-assembled into spherical nanoparticles","doi":"10.1093/rb/rbac096","comments":"DLS measurements showed that the mean diameters of the Dex-g-OA micelles were 338.1 and 549.7 nm, respectively. (confidence: high)"},{"id":2,"conjugate":"dextran-b-PLGA (DexbLG)","polymer":"poly(DL-lactide-co-glycolide) (PLGA)","carbohydrate":"dextran (Mw ~6000)","method":"Experiment","shape":"spherical core-shell micelle","size":"~70-80 nm (empty); 122-206 nm drug-loaded (DLS/TEM)","conditions":"aqueous, dialysis, DLS+TEM","conditions_detail":"PLGA hydrophobic core, dextran hydrophilic shell; doxorubicin-loaded micelles grew with drug content","doi":"10.2147/IJN.S19491","comments":"DexbLG block copolymer formed polymeric micelles with a narrow size distribution; TEM shows micelles smaller than 100 nm. (confidence: high)"},{"id":3,"conjugate":"hyaluronic acid-g-PLGA (HAgLG)","polymer":"poly(DL-lactide-co-glycolide) (PLGA)","carbohydrate":"hyaluronic acid","method":"Experiment","shape":"spherical core-shell micelle","size":"~81 nm, <100 nm (DLS/TEM)","conditions":"aqueous, dialysis, DLS+TEM","conditions_detail":"HA hydrated outer shell, PLGA hydrophobic inner core; for tumor targeting","doi":"10.3390/ijms150916057","comments":"Polymeric micelles of HAgLG have small particle sizes less than 100 nm and are spherical in shape. (confidence: high)"},{"id":4,"conjugate":"hyaluronan-ferulic acid-HEG-oleic acid (HA-FA-HEG-OA)","polymer":"hexa(ethylene glycol)/oleic acid graft","carbohydrate":"hyaluronan","method":"Experiment","shape":"spherical nanoparticle","size":"291 nm empty, 234 nm loaded (DLS)","conditions":"aqueous, DLS+TEM","conditions_detail":"hyaluronan grafted with ferulic acid via HEG spacers to oleic acid; for olanzapine delivery","doi":"10.3390/pharmaceutics11120675","comments":"HA-FA-HEG-OA nano-aggregates appeared as spherical objects, slightly smaller by TEM than DLS due to dehydration shrinkage. (confidence: high)"},{"id":5,"conjugate":"stearamido-beta-cyclodextrin (S-beta-CD)","polymer":"octadecanamido (stearyl amide) chain","carbohydrate":"beta-cyclodextrin","method":"Experiment","shape":"nano-vesicle","size":"diameter 53.4 nm (DLS), 24.1 nm (TEM)","conditions":"water, DLS+TEM+fluorescence","conditions_detail":"amphiphilic fatty amide-beta-CD conjugate self-assembles into nano-vesicles; oleamido analogue 77.8 nm DLS; for retinol stabilization","doi":"10.3390/molecules21070963","comments":"The self-assembled composites of S-beta-CD show an average diameter of 53.4 nm in the DLS profile; O-beta-CD has a larger mean diameter of 77.8 nm. (confidence: high)"},{"id":6,"conjugate":"PEGylated ethyl cellulose (EC-PEG)","polymer":"poly(ethylene glycol) (PEG)","carbohydrate":"ethyl cellulose","method":"Experiment","shape":"micelle","size":"~80 nm (blank); 153.5-350.5 nm loaded","conditions":"aqueous, DLS+TEM+CMC","conditions_detail":"EC-PEG amphiphile self-assembles into nano-micelles; DOX loading increased size; CMC by pyrene fluorescence","doi":"10.1039/D1RA04242D","comments":"the average size of the nano-micelles was recorded to be ~80 nm. (confidence: high)"},{"id":7,"conjugate":"PLA-b-(PTA-g-mannose)","polymer":"poly(lactic acid)/polyester (OCA-based)","carbohydrate":"mannose","method":"Experiment","shape":"spherical micelle","size":"hydrodynamic diameter 80-130 nm (DLS/TEM)","conditions":"aqueous, DLS+TEM","conditions_detail":"biodegradable micelle for mannose-mediated targeted drug delivery; size grows with mannose block length","doi":"10.1002/marc.201400650","comments":"The micelles possessed hydrodynamic diameters of 80-130 nm; increasing the hydrophilic PTA-g-mannose block length increased particle size. (confidence: high)"},{"id":8,"conjugate":"mannosylated PEG-PCL brush copolymers","polymer":"poly(ethylene glycol)-poly(epsilon-caprolactone) (PEG-PCL)","carbohydrate":"mannose","method":"Experiment","shape":"nanoparticle (small spherical aggregate)","size":"Dh 7.5-11.3 nm (DLS); 10-20 nm (TEM)","conditions":"aqueous and other media, DLS+TEM","conditions_detail":"linear and four-arm mannosylated PEG-PCL brush copolymers self-assemble into lectin-binding nanoparticles","doi":"10.3762/bjnano.10.212","comments":"In any medium, polymers formed nanoparticles with Dh varying from 7.5 to 11.3 nm. (confidence: high)"},{"id":9,"conjugate":"galactose diblock copolymer (PGalSMA-PGMA)-PHPMA","polymer":"poly(2-hydroxypropyl methacrylate) (PHPMA)/poly(glycerol monomethacrylate) (PGMA)","carbohydrate":"galactose (PGalSMA)","method":"Experiment","shape":"spheres / worm-like micelles / vesicles (tunable)","size":"morphology set by PHPMA DP; worms form free-standing gels at 20C","conditions":"concentrated aqueous, RAFT PISA, TEM+DLS+rheology","conditions_detail":"galactosylated diblock copolymer nano-objects via RAFT PISA; worms form thermo-reversible gels; bind galectins","doi":"10.1021/ja407033x","comments":"a 9:1 PGMA51/PGalSMA34 ratio allowed synthesis of well-defined spheres, worms, or vesicles depending on the core-block DP. (confidence: high)"},{"id":10,"conjugate":"PDMAEMA-b-PMAIGP galactose glycopolymer","polymer":"poly(2-dimethylaminoethyl methacrylate) (PDMAEMA)","carbohydrate":"galactose (MAIGP)","method":"Experiment","shape":"spheres, worms, lamellae, multilayer lamellae, complex vesicles","size":"~40 nm to ~1.0 um (DLS/TEM/cryo-TEM/SEM)","conditions":"RAFT dispersion polymerization, 5-20% solids","conditions_detail":"highly ordered glyco-inside nano-assemblies; morphology controlled by PMAIGP DP and solids content","doi":"10.1002/anie.202015692","comments":"a series of highly ordered glyco-inside nano-assemblies (spheres, worms, lamellae, multilayer lamellae and complex vesicles) were fabricated. (confidence: high)"},{"id":11,"conjugate":"beta-D-glucose glycopolymer-PLA hybrid block copolymer","polymer":"branched poly(lactic acid) (PLA)","carbohydrate":"beta-D-glucose (pendant glycopolymer)","method":"Experiment","shape":"vesicles (~30% glyco), mixed (~38%), core-shell micelles (~66%)","size":"vesicles ~120 nm; core-shell micelles ~41 nm","conditions":"aqueous, AFM+TEM+DLS","conditions_detail":"hybrid block copolymers of beta-D-glucose glycopolymer and branched PLA via thiol-ene; morphology depends on glyco fraction","doi":"10.1021/acs.biomac.4c00885","comments":"The Glc 31:69 copolymers self-assemble into spherical bilayer vesicles roughly 120 nm in diameter. (confidence: high)"},{"id":12,"conjugate":"glycopolymer-PEG-PLA (Man-/Tre-/G7-PEG-PLA)","polymer":"poly(ethylene glycol)-poly(lactic acid) (PEG-PLA)","carbohydrate":"mannose, trehalose, maltoheptaose","method":"Experiment","shape":"micelle (PLA core, carbohydrate surface)","size":"~27-31 nm, PDI 0.20-0.28 (DLS)","conditions":"aqueous, DLS + ConA binding","conditions_detail":"glycopolymer micelles for antibiotic delivery; carbohydrate surface confirmed by Concanavalin A assay","doi":"10.3390/molecules28104031","comments":"the glycopolymer micelles had a similar size to PEG-PLA around 27-31 nm and PDI 0.20-0.28. (confidence: high)"},{"id":13,"conjugate":"octylamine-grafted oxidized sodium alginate (Ugi-OSAOcT)","polymer":"octylamine (hydrophobic graft via Ugi reaction)","carbohydrate":"sodium alginate (oxidized)","method":"Experiment","shape":"spherical micelle","size":"135.7-196.5 nm (DLS); 90-110 nm (TEM)","conditions":"aqueous, DLS+TEM, zeta potential","conditions_detail":"amphiphilic biopolymer from oxidized alginate via one-pot Ugi reaction; zeta -32.8 to -38.2 mV","doi":"10.3390/polym14040694","comments":"All micelles were almost spherical with a size of 90-110 nm and well-dispersed with no aggregation. (confidence: high)"},{"id":14,"conjugate":"beta-dodecyl maltoside (beta-C12G2)","polymer":"dodecyl (C12 alkyl chain)","carbohydrate":"maltose (beta-anomer)","method":"Simulation","shape":"oblate/ellipsoidal micelle","size":"Rg = 25.4 A; aggregation number 132","conditions":"all-atom MD, explicit water","conditions_detail":"All-atom MD of preformed micelle; CHARMM36-Opt and GLYCAM06 force fields; beta-anomer; Nagg 132","doi":"10.1021/jp109545v","comments":"The computed radius of gyration is 20.2 A and 25.4 A for the alpha- and beta-anomer micelles, respectively. (confidence: high)"},{"id":15,"conjugate":"alpha-dodecyl maltoside (alpha-C12G2)","polymer":"dodecyl (C12 alkyl chain)","carbohydrate":"maltose (alpha-anomer)","method":"Simulation","shape":"ellipsoidal micelle","size":"Rg = 20.2 A; aggregation number 75","conditions":"all-atom MD, explicit water","conditions_detail":"All-atom MD; CHARMM36/GLYCAM06; alpha-anomer; semi-axis ratio ~1.20; Nagg 75","doi":"10.1021/jp109545v","comments":"the alpha-C12G2 micelles have an average major-to-minor semi-axis ratio close to 1.20 whereas the beta-C12G2 micelle has a more pronounced oblate shape. (confidence: high)"},{"id":16,"conjugate":"alkyl maltoside MALTO12","polymer":"C12 alkyl chain","carbohydrate":"maltose","method":"Simulation","shape":"spherical micelle","size":"CMC 0.29 mM (MALTO12); Nagg 19 (MALTO8)","conditions":"DPD, aqueous","conditions_detail":"Dissipative particle dynamics; parameters from SSIMPLE / B3LYP/6-31G* electrostatic potentials","doi":"10.1021/acs.jpcb.1c00480","comments":"MALTO12 forms micelles with spherical shapes. (confidence: high)"},{"id":17,"conjugate":"alkyl glucoside GLUCO12","polymer":"C12 alkyl chain","carbohydrate":"glucose (glucoside)","method":"Simulation","shape":"elongated/oblate micelle","size":"Nagg 252 (GLUCO12); CMC 1.87 mM (GLUCO10)","conditions":"DPD, aqueous","conditions_detail":"Dissipative particle dynamics; parameters from molecular mechanics and B3LYP/6-31G*","doi":"10.1021/acs.jpcb.1c00480","comments":"GLUCO systems show elongated micelles with an oblate form. (confidence: high)"},{"id":18,"conjugate":"mannose amphiphiles (high DP)","polymer":"hydrophobic alkyl/lipid tail","carbohydrate":"mannose (oligomannose head)","method":"Simulation","shape":"spherical micelle","size":"not reported numerically","conditions":"MD in aqueous media","conditions_detail":"MD in aqueous media; high degree of polymerization amphiphiles; validated vs DLS, SAXS, cryo-TEM","doi":"10.1021/acs.langmuir.2c00579","comments":"high-DP amphiphiles self-assemble into spherical micelles irrespective of the hydroxyl group presence; low-DP amphiphiles form cylindrical micelles. (confidence: high)"},{"id":19,"conjugate":"mannose amphiphiles (low DP)","polymer":"hydrophobic alkyl/lipid tail","carbohydrate":"mannose (single hydrophilic moiety)","method":"Simulation","shape":"cylindrical (rod-like) micelle","size":"not reported numerically","conditions":"coarse-grained MD, aqueous","conditions_detail":"CG MD of self-assembly pathway: clusters -> spherical micelles with sugar shell -> merge/elongate into rods","doi":"10.1021/acs.langmuir.2c00579","comments":"these spherical micelles merge and lengthen into rod-like micelles. (confidence: high)"},{"id":20,"conjugate":"chitosan-citral microcapsule","polymer":"citral (essential oil core)","carbohydrate":"chitosan (wall material)","method":"Simulation","shape":"spherical core-shell microcapsule","size":"simulation box 200x200x200 A^3; bead radius 2.98 A","conditions":"DPD, aqueous","conditions_detail":"Dissipative particle dynamics; CG beads, DP 20; three-layer hydrophilic core/shell with hydrophobic medium layer","doi":"10.3390/polym17050678","comments":"Cts-citral forms a three-layer core-shell with hydrophilic core and shell layers and a hydrophobic medium layer. (confidence: high)"}]}