{"count":839,"next":"http://glycodata.org/api/gdd/glyco-properties/?format=json&page=39","previous":"http://glycodata.org/api/gdd/glyco-properties/?format=json&page=37","results":[{"id":741,"dataset":"heparin","entity":"certoparin","entity_group":"","entity_class":"LMWH","property":"molecular weight","property_key":"molecular_weight","value":"3.8","unit":"kDa","value_reported":"3.8","unit_reported":"kDa","method":"Review","method_detail":"lowest average molecular weight among LMWHs (3800 Da)","conditions":"lowest average molecular weight among LMWHs (3800 Da)","conditions_detail":"lowest average molecular weight among LMWHs (3800 Da)","doi":"10.1007/s00228-015-1880-5","source_url":"https://doi.org/10.1007/s00228-015-1880-5","year":"2015","confidence":"high","comments":"\"Tinzaparin has the highest average molecular weight (6500 Da), while certoparin has the lowest average molecular weight (3800 Da)\"  [Atiq F, van den Bemt PMLA, Leebeek FWG, et al., 2015, confidence: high]"},{"id":742,"dataset":"heparin","entity":"tinzaparin","entity_group":"","entity_class":"LMWH","property":"molecular weight","property_key":"molecular_weight","value":"6.5","unit":"kDa","value_reported":"6.5","unit_reported":"kDa","method":"Review","method_detail":"highest average molecular weight among LMWHs (6500 Da)","conditions":"highest average molecular weight among LMWHs (6500 Da)","conditions_detail":"highest average molecular weight among LMWHs (6500 Da)","doi":"10.1007/s00228-015-1880-5","source_url":"https://doi.org/10.1007/s00228-015-1880-5","year":"2015","confidence":"high","comments":"\"Tinzaparin has the highest average molecular weight (6500 Da), while certoparin has the lowest average molecular weight (3800 Da)\"  — corroborates Dimakakos 2017 value of 6500 Da  [Atiq F, van den Bemt PMLA, Leebeek FWG, et al., 2015, confidence: high]"},{"id":743,"dataset":"heparin","entity":"reviparin","entity_group":"","entity_class":"LMWH","property":"anti-Xa/IIa ratio","property_key":"anti_xa_iia_ratio","value":"5.05","unit":"ratio","value_reported":"3.6-6.5","unit_reported":"ratio","method":"Review","method_detail":"anti-Xa/anti-IIa ratio (highest end of LMWH range)","conditions":"anti-Xa/anti-IIa ratio (highest end of LMWH range)","conditions_detail":"anti-Xa/anti-IIa ratio (highest end of LMWH range)","doi":"10.1007/s00228-015-1880-5","source_url":"https://doi.org/10.1007/s00228-015-1880-5","year":"2015","confidence":"high","comments":"\"anti-Xa/anti-IIa activity ratios range between 1.5 and 2.5 (tinzaparin and certoparin) to 3.6–6.5 (reviparin)\"  [Atiq F, van den Bemt PMLA, Leebeek FWG, et al., 2015, confidence: high]"},{"id":744,"dataset":"heparin","entity":"certoparin","entity_group":"","entity_class":"LMWH","property":"anti-Xa/IIa ratio","property_key":"anti_xa_iia_ratio","value":"2","unit":"ratio","value_reported":"1.5-2.5","unit_reported":"ratio","method":"Review","method_detail":"anti-Xa/anti-IIa ratio (low end of LMWH range, grouped with tinzaparin)","conditions":"anti-Xa/anti-IIa ratio (low end of LMWH range, grouped with tinzaparin)","conditions_detail":"anti-Xa/anti-IIa ratio (low end of LMWH range, grouped with tinzaparin)","doi":"10.1007/s00228-015-1880-5","source_url":"https://doi.org/10.1007/s00228-015-1880-5","year":"2015","confidence":"high","comments":"\"anti-Xa/anti-IIa activity ratios range between 1.5 and 2.5 (tinzaparin and certoparin) to 3.6–6.5 (reviparin)\"  [Atiq F, van den Bemt PMLA, Leebeek FWG, et al., 2015, confidence: high]"},{"id":745,"dataset":"heparin","entity":"fondaparinux","entity_group":"","entity_class":"synthetic","property":"molecular weight","property_key":"molecular_weight","value":"1.728","unit":"kDa","value_reported":"1728","unit_reported":"Da","method":"Review","method_detail":"molecular weight of synthetic pentasaccharide fondaparinux","conditions":"molecular weight of synthetic pentasaccharide fondaparinux","conditions_detail":"molecular weight of synthetic pentasaccharide fondaparinux","doi":"10.1186/1477-9560-9-5","source_url":"https://doi.org/10.1186/1477-9560-9-5","year":"2011","confidence":"high","comments":"\"Fondaparinux is a synthetic pentasaccharide with a molecular weight of 1,728 Da containing an AT-binding domain modified from that found in UFH and LMWHs to increase its affinity for AT.\"  — 1728 Da corroborated by De Caterina 2007, Bergqvist 2006, Zhang 2022, Gao 2024  [Fareed J, Adiguzel C, Thethi I, 2011, confidence: high]"},{"id":746,"dataset":"heparin","entity":"fondaparinux","entity_group":"","entity_class":"synthetic","property":"anti-Xa activity","property_key":"anti_xa_activity","value":"700","unit":"IU/mg","value_reported":"700","unit_reported":"IU/mg","method":"Review","method_detail":"specific anti-Xa activity ~700 anti-Xa U/mg (~7x that of LMWHs)","conditions":"specific anti-Xa activity ~700 anti-Xa U/mg (~7x that of LMWHs)","conditions_detail":"specific anti-Xa activity ~700 anti-Xa U/mg (~7x that of LMWHs)","doi":"10.1093/eurheartj/ehl492","source_url":"https://doi.org/10.1093/eurheartj/ehl492","year":"2007","confidence":"high","comments":"\"The specific anti-Xa activity of fondaparinux is about seven-fold higher than that of LMWHs (about 700 anti-Xa U/ mg and 100 anti-Xa U/mg, respectively).\"  — U/mg = IU/mg; ~700 U/mg corroborated by Gao 2024 (BMC Surgery)  [De Caterina R, Husted S, Wallentin L, et al., 2007, confidence: high]"},{"id":747,"dataset":"heparin","entity":"fondaparinux","entity_group":"","entity_class":"synthetic","property":"anti-IIa activity","property_key":"anti_iia_activity","value":"0","unit":"IU/mg","value_reported":"0","unit_reported":"IU/mg","method":"Review","method_detail":"no anti-IIa (anti-thrombin) activity; selective Factor Xa inhibitor","conditions":"no anti-IIa (anti-thrombin) activity; selective Factor Xa inhibitor","conditions_detail":"no anti-IIa (anti-thrombin) activity; selective Factor Xa inhibitor","doi":"10.1186/1477-9560-9-5","source_url":"https://doi.org/10.1186/1477-9560-9-5","year":"2011","confidence":"high","comments":"\"Fondaparinux cannot inhibit thrombin and its anticoagulant activity is entirely dependent on its ability to selectively inhibit Factor Xa\"  — Qualitative: anti-IIa activity is effectively zero (cannot inhibit thrombin/factor IIa)  [Fareed J, Adiguzel C, Thethi I, 2011, confidence: high]"},{"id":748,"dataset":"heparin","entity":"fondaparinux","entity_group":"","entity_class":"synthetic","property":"anti-Xa activity","property_key":"anti_xa_activity","value":"700","unit":"IU/mg","value_reported":"700","unit_reported":"IU/mg","method":"Review","method_detail":"specific anti-Xa activity ~700 units/mg (vs ~100 units/mg for LMWHs)","conditions":"specific anti-Xa activity ~700 units/mg (vs ~100 units/mg for LMWHs)","conditions_detail":"specific anti-Xa activity ~700 units/mg (vs ~100 units/mg for LMWHs)","doi":"10.1186/s12893-024-02440-0","source_url":"https://doi.org/10.1186/s12893-024-02440-0","year":"2024","confidence":"high","comments":"\"fondaparinux sodium has been reported to have higher specific anti-Xa activity than LMWHs (approximately 700 units/mg and 100 units/mg, respectively)\"  — Independent corroboration of De Caterina 2007 value  [Gao X, Jin X, Huang R, et al., 2024, confidence: high]"},{"id":749,"dataset":"heparin","entity":"fondaparinux","entity_group":"","entity_class":"synthetic","property":"molecular weight","property_key":"molecular_weight","value":"1.728","unit":"kDa","value_reported":"1728","unit_reported":"Da","method":"Review","method_detail":"molecular weight 1728 Da (ultralow-molecular-weight heparin / synthetic pentasaccharide)","conditions":"molecular weight 1728 Da (ultralow-molecular-weight heparin / synthetic pentasaccharide)","conditions_detail":"molecular weight 1728 Da (ultralow-molecular-weight heparin / synthetic pentasaccharide)","doi":"10.1021/jacsau.2c00537","source_url":"https://doi.org/10.1021/jacsau.2c00537","year":"2022","confidence":"high","comments":"\"ultralow-molecular weight heparin (UMWH, molecular weight 1500–3000 Da) such as synthetic pentasaccharide fondaparinux (molecular weight 1728 Da).\"  — Also gives UFH ~16000 Da and LMWH 3500-6000 Da in same sentence  [Zhang L, Liu Y, Xu Z, et al., 2022, confidence: high]"},{"id":750,"dataset":"heparin","entity":"danaparoid","entity_group":"","entity_class":"heparinoid (other)","property":"molecular weight","property_key":"molecular_weight","value":"4.4","unit":"kDa","value_reported":"4200-4600","unit_reported":"Da","method":"Experiment","method_detail":"weight-average molecular weight (Mw) by HP-SEC-TDA of danaparoid API samples","conditions":"weight-average molecular weight (Mw) by HP-SEC-TDA of danaparoid API samples","conditions_detail":"weight-average molecular weight (Mw) by HP-SEC-TDA of danaparoid API samples | Mn Da: 3300-3400 | polydispersity: 1.27-1.36","doi":"10.3390/molecules22071116","source_url":"https://doi.org/10.3390/molecules22071116","year":"2017","confidence":"high","comments":"\"Danaparoid was a low-molecular-weight mixture of HS, CS, and DS, confirmed by experimental weight average molecular weight (Mw) ranging from 4200 to 4600 Da.\"  — Mn 3300-3400 Da; mixture of heparan sulfate, dermatan sulfate, chondroitin sulfate  [Gardini C, Urso E, Guerrini M, et al., 2017, confidence: high]"},{"id":751,"dataset":"heparin","entity":"danaparoid","entity_group":"","entity_class":"heparinoid (other)","property":"anti-Xa/IIa ratio","property_key":"anti_xa_iia_ratio","value":"> UFH","unit":"ratio","value_reported":"> UFH","unit_reported":"ratio","method":"Review","method_detail":"anti-factor Xa/IIa ratio greater than that of unfractionated heparin (qualitative)","conditions":"anti-factor Xa/IIa ratio greater than that of unfractionated heparin (qualitative)","conditions_detail":"anti-factor Xa/IIa ratio greater than that of unfractionated heparin (qualitative)","doi":"10.1186/cc6119","source_url":"https://doi.org/10.1186/cc6119","year":"2007","confidence":"medium","comments":"\"Danaparoid is a low-molecular-weight heparinoid consisting of a mixture of heparan sulphate (84%), dermatan sulphate (12%), and small amounts of chondroitin sulphate (4%). Its pharmacological effect is exerted primarily by the inhibition of factors Xa and IIa at a ratio greater than that of unfractionated heparin\"  — Qualitative ratio only; danaparoid composition: 84% HS, 12% DS, 4% CS  [de Pont AC, Hofstra JJ, Pik DR, et al., 2007, confidence: medium]"},{"id":752,"dataset":"heparin","entity":"danaparoid (heparan sulfate component)","entity_group":"","entity_class":"heparan sulfate","property":"molecular weight","property_key":"molecular_weight","value":"3.4","unit":"kDa","value_reported":"3300-3500","unit_reported":"Da","method":"Experiment","method_detail":"weight-average Mw of the heparan sulfate (HS) fraction isolated from danaparoid","conditions":"weight-average Mw of the heparan sulfate (HS) fraction isolated from danaparoid","conditions_detail":"weight-average Mw of the heparan sulfate (HS) fraction isolated from danaparoid | note: enriched HS fraction, CS/DS still present 5-14%","doi":"10.3390/molecules22071116","source_url":"https://doi.org/10.3390/molecules22071116","year":"2017","confidence":"high","comments":"\"their weight average Mw was found in the range from 3300 to 3500 Da, consistent with SEC fractions data.\"  — HS is the major component of danaparoid; LMW heparan sulfate  [Gardini C, Urso E, Guerrini M, et al., 2017, confidence: high]"},{"id":753,"dataset":"heparin","entity":"heparan sulfate","entity_group":"","entity_class":"heparan sulfate","property":"molecular weight","property_key":"molecular_weight","value":"55","unit":"kDa","value_reported":"10-100","unit_reported":"kDa","method":"Review","method_detail":"typical molecular mass range of heparan sulfate glycosaminoglycan chains","conditions":"typical molecular mass range of heparan sulfate glycosaminoglycan chains","conditions_detail":"typical molecular mass range of heparan sulfate glycosaminoglycan chains","doi":"10.1074/jbc.m110.148874","source_url":"https://doi.org/10.1074/jbc.m110.148874","year":"2011","confidence":"high","comments":"\"These linear, sulfated glycosaminoglycans have molecular masses that typically range from 10 to 100 kDa (5).\"  — native heparan sulfate (J Biol Chem)  [Murali S, Leong DFM, Lee JJL, et al., 2011, confidence: high]"},{"id":754,"dataset":"heparin","entity":"heparan sulfate","entity_group":"","entity_class":"heparan sulfate","property":"molecular weight","property_key":"molecular_weight","value":"50","unit":"kDa","value_reported":"30-70","unit_reported":"kDa","method":"Review","method_detail":"molecular weight of cell-surface heparan sulfate (40-300 sugar residues, ~20-150 nm long)","conditions":"molecular weight of cell-surface heparan sulfate (40-300 sugar residues, ~20-150 nm long)","conditions_detail":"molecular weight of cell-surface heparan sulfate (40-300 sugar residues, ~20-150 nm long)","doi":"10.1128/jvi.02222-18","source_url":"https://doi.org/10.1128/jvi.02222-18","year":"2019","confidence":"high","comments":"\"Heparan sulfate is a 30-to 70-kDa linear polysaccharide (40 to 300 sugar residues and approximately 20 to 150 nm long) composed of alternating sulfated (NS) domains and unsulfated (NA) domains\"  [Dhindwal S, Avila B, Feng S, et al., 2019, confidence: high]"},{"id":755,"dataset":"heparin","entity":"heparan sulfate (male mouse liver)","entity_group":"","entity_class":"heparan sulfate","property":"molecular weight","property_key":"molecular_weight","value":"100","unit":"kDa","value_reported":"100","unit_reported":"kDa","method":"Experiment","method_detail":"HS chain length determined by molecular sieving (~100 kDa, 30-40 disaccharide repeats); male adult mouse liver","conditions":"HS chain length determined by molecular sieving (~100 kDa, 30-40 disaccharide repeats); male adult mouse liver","conditions_detail":"HS chain length determined by molecular sieving (~100 kDa, 30-40 disaccharide repeats); male adult mouse liver | source: male adult mouse liver | disaccharide repeats: 30-40","doi":"10.1074/jbc.m110.148874","source_url":"https://doi.org/10.1074/jbc.m110.148874","year":"2011","confidence":"high","comments":"\"size determination showed that HS chain lengths were ~100 and ~22 kDa, comprising 30-40 and 6-8 disaccharide repeats, respectively.\"  — male vs female liver HS  [Murali S, Leong DFM, Lee JJL, et al., 2011, confidence: high]"},{"id":756,"dataset":"heparin","entity":"heparan sulfate (female mouse liver)","entity_group":"","entity_class":"heparan sulfate","property":"molecular weight","property_key":"molecular_weight","value":"22","unit":"kDa","value_reported":"22","unit_reported":"kDa","method":"Experiment","method_detail":"HS chain length determined by molecular sieving (~22 kDa, 6-8 disaccharide repeats); female adult mouse liver","conditions":"HS chain length determined by molecular sieving (~22 kDa, 6-8 disaccharide repeats); female adult mouse liver","conditions_detail":"HS chain length determined by molecular sieving (~22 kDa, 6-8 disaccharide repeats); female adult mouse liver | source: female adult mouse liver | disaccharide repeats: 6-8","doi":"10.1074/jbc.m110.148874","source_url":"https://doi.org/10.1074/jbc.m110.148874","year":"2011","confidence":"high","comments":"\"size determination showed that HS chain lengths were ~100 and ~22 kDa, comprising 30-40 and 6-8 disaccharide repeats, respectively.\"  [Murali S, Leong DFM, Lee JJL, et al., 2011, confidence: high]"},{"id":757,"dataset":"heparin","entity":"heparan sulfate (CHO cell, nascent)","entity_group":"","entity_class":"heparan sulfate","property":"molecular weight","property_key":"molecular_weight","value":"81","unit":"kDa","value_reported":"81","unit_reported":"kDa","method":"Experiment","method_detail":"nascent CHO cell heparan sulfate chains, ~370 residues long (81 kDa)","conditions":"nascent CHO cell heparan sulfate chains, ~370 residues long (81 kDa)","conditions_detail":"nascent CHO cell heparan sulfate chains, ~370 residues long (81 kDa) | source: Chinese hamster ovary (CHO) cell | residues: 370","doi":"10.1074/jbc.272.14.9078","source_url":"https://doi.org/10.1074/jbc.272.14.9078","year":"1997","confidence":"high","comments":"\"Nascent CHO HS chains are on average 370 residues long, as estimated from their molecular mass (81 kDa) and average sugar unit mass (220 Da).\"  [Tumova S, Bame KJ, 1997, confidence: high]"},{"id":758,"dataset":"heparin","entity":"heparan sulfate (bovine vitreous humour)","entity_group":"","entity_class":"heparan sulfate","property":"molecular weight","property_key":"molecular_weight","value":"204","unit":"kDa","value_reported":"204","unit_reported":"kDa","method":"Experiment","method_detail":"average molecular weight of heparan sulfate from bovine eye vitreous humour","conditions":"average molecular weight of heparan sulfate from bovine eye vitreous humour","conditions_detail":"average molecular weight of heparan sulfate from bovine eye vitreous humour | source: bovine eye vitreous humour","doi":"10.1007/s10719-017-9808-1","source_url":"https://doi.org/10.1007/s10719-017-9808-1","year":"2018","confidence":"high","comments":"\"The average molecular weights of CS and HS were 148 kDa and 204 kDa, respectively.\"  — tissue-derived HS; high MW  [Peng Y, Yu Y, Lin L, et al., 2018, confidence: high]"},{"id":759,"dataset":"heparin","entity":"heparin oligosaccharide (18-mer / minimum thrombin-bridging chain)","entity_group":"","entity_class":"heparin oligosaccharide","property":"molecular weight","property_key":"molecular_weight","value":"5.4","unit":"kDa","value_reported":"5400","unit_reported":"Da","method":"Review","method_detail":"molecular weight of the 18-saccharide chain required for thrombin (anti-IIa) potentiation","conditions":"molecular weight of the 18-saccharide chain required for thrombin (anti-IIa) potentiation","conditions_detail":"molecular weight of the 18-saccharide chain required for thrombin (anti-IIa) potentiation | saccharides: 18","doi":"10.1124/pharmrev.122.000684","source_url":"https://doi.org/10.1124/pharmrev.122.000684","year":"2023","confidence":"high","comments":"\"The 18 saccharides required for thrombin-AT potentiation equates to 5400 daltons in weight and explains some of the differences in anti-Xa and anti-IIa activity of low molecular weight heparins\"  — Chains <5400 Da have anti-Xa activity only; mechanistic threshold  [Hogwood J, Mulloy B, Lever R, Gray E, Page CP, 2023, confidence: high]"},{"id":760,"dataset":"heparin","entity":"heparin pentasaccharide (AT-binding A-domain)","entity_group":"","entity_class":"heparin oligosaccharide","property":"molecular weight","property_key":"molecular_weight","value":"1.7","unit":"kDa","value_reported":"1700","unit_reported":"Da","method":"Experiment","method_detail":"molecular weight of the minimum antithrombin-binding pentasaccharide (lower bound of MW series studied)","conditions":"molecular weight of the minimum antithrombin-binding pentasaccharide (lower bound of MW series studied)","conditions_detail":"molecular weight of the minimum antithrombin-binding pentasaccharide (lower bound of MW series studied)","doi":"10.1046/j.1538-7836.2003.00211.x","source_url":"https://doi.org/10.1046/j.1538-7836.2003.00211.x","year":"2003","confidence":"high","comments":"\"10 heparins with molecular weights ranging from 1700 (pentasaccharide) to 20 000\"  — natural pentasaccharide ~1700 Da (cf. synthetic fondaparinux 1728 Da)  [Al Dieri R, Wagenvoord R, van Dedem GWK, et al., 2003, confidence: high]"}]}