Glyco Property List
Pooled literature properties (glycanDB). Optional filters: ?dataset=uv_vis&property_key=...
GET /api/gdd/glyco-properties/?format=api&page=38
{ "count": 839, "next": "http://glycodata.org/api/gdd/glyco-properties/?format=api&page=39", "previous": "http://glycodata.org/api/gdd/glyco-properties/?format=api&page=37", "results": [ { "id": 741, "dataset": "heparin", "entity": "certoparin", "entity_group": "", "entity_class": "LMWH", "property": "molecular weight", "property_key": "molecular_weight", "value": "3.8", "unit": "kDa", "value_reported": "3.8", "unit_reported": "kDa", "method": "Review", "method_detail": "lowest average molecular weight among LMWHs (3800 Da)", "conditions": "lowest average molecular weight among LMWHs (3800 Da)", "conditions_detail": "lowest average molecular weight among LMWHs (3800 Da)", "doi": "10.1007/s00228-015-1880-5", "source_url": "https://doi.org/10.1007/s00228-015-1880-5", "year": "2015", "confidence": "high", "comments": "\"Tinzaparin has the highest average molecular weight (6500 Da), while certoparin has the lowest average molecular weight (3800 Da)\" [Atiq F, van den Bemt PMLA, Leebeek FWG, et al., 2015, confidence: high]" }, { "id": 742, "dataset": "heparin", "entity": "tinzaparin", "entity_group": "", "entity_class": "LMWH", "property": "molecular weight", "property_key": "molecular_weight", "value": "6.5", "unit": "kDa", "value_reported": "6.5", "unit_reported": "kDa", "method": "Review", "method_detail": "highest average molecular weight among LMWHs (6500 Da)", "conditions": "highest average molecular weight among LMWHs (6500 Da)", "conditions_detail": "highest average molecular weight among LMWHs (6500 Da)", "doi": "10.1007/s00228-015-1880-5", "source_url": "https://doi.org/10.1007/s00228-015-1880-5", "year": "2015", "confidence": "high", "comments": "\"Tinzaparin has the highest average molecular weight (6500 Da), while certoparin has the lowest average molecular weight (3800 Da)\" — corroborates Dimakakos 2017 value of 6500 Da [Atiq F, van den Bemt PMLA, Leebeek FWG, et al., 2015, confidence: high]" }, { "id": 743, "dataset": "heparin", "entity": "reviparin", "entity_group": "", "entity_class": "LMWH", "property": "anti-Xa/IIa ratio", "property_key": "anti_xa_iia_ratio", "value": "5.05", "unit": "ratio", "value_reported": "3.6-6.5", "unit_reported": "ratio", "method": "Review", "method_detail": "anti-Xa/anti-IIa ratio (highest end of LMWH range)", "conditions": "anti-Xa/anti-IIa ratio (highest end of LMWH range)", "conditions_detail": "anti-Xa/anti-IIa ratio (highest end of LMWH range)", "doi": "10.1007/s00228-015-1880-5", "source_url": "https://doi.org/10.1007/s00228-015-1880-5", "year": "2015", "confidence": "high", "comments": "\"anti-Xa/anti-IIa activity ratios range between 1.5 and 2.5 (tinzaparin and certoparin) to 3.6–6.5 (reviparin)\" [Atiq F, van den Bemt PMLA, Leebeek FWG, et al., 2015, confidence: high]" }, { "id": 744, "dataset": "heparin", "entity": "certoparin", "entity_group": "", "entity_class": "LMWH", "property": "anti-Xa/IIa ratio", "property_key": "anti_xa_iia_ratio", "value": "2", "unit": "ratio", "value_reported": "1.5-2.5", "unit_reported": "ratio", "method": "Review", "method_detail": "anti-Xa/anti-IIa ratio (low end of LMWH range, grouped with tinzaparin)", "conditions": "anti-Xa/anti-IIa ratio (low end of LMWH range, grouped with tinzaparin)", "conditions_detail": "anti-Xa/anti-IIa ratio (low end of LMWH range, grouped with tinzaparin)", "doi": "10.1007/s00228-015-1880-5", "source_url": "https://doi.org/10.1007/s00228-015-1880-5", "year": "2015", "confidence": "high", "comments": "\"anti-Xa/anti-IIa activity ratios range between 1.5 and 2.5 (tinzaparin and certoparin) to 3.6–6.5 (reviparin)\" [Atiq F, van den Bemt PMLA, Leebeek FWG, et al., 2015, confidence: high]" }, { "id": 745, "dataset": "heparin", "entity": "fondaparinux", "entity_group": "", "entity_class": "synthetic", "property": "molecular weight", "property_key": "molecular_weight", "value": "1.728", "unit": "kDa", "value_reported": "1728", "unit_reported": "Da", "method": "Review", "method_detail": "molecular weight of synthetic pentasaccharide fondaparinux", "conditions": "molecular weight of synthetic pentasaccharide fondaparinux", "conditions_detail": "molecular weight of synthetic pentasaccharide fondaparinux", "doi": "10.1186/1477-9560-9-5", "source_url": "https://doi.org/10.1186/1477-9560-9-5", "year": "2011", "confidence": "high", "comments": "\"Fondaparinux is a synthetic pentasaccharide with a molecular weight of 1,728 Da containing an AT-binding domain modified from that found in UFH and LMWHs to increase its affinity for AT.\" — 1728 Da corroborated by De Caterina 2007, Bergqvist 2006, Zhang 2022, Gao 2024 [Fareed J, Adiguzel C, Thethi I, 2011, confidence: high]" }, { "id": 746, "dataset": "heparin", "entity": "fondaparinux", "entity_group": "", "entity_class": "synthetic", "property": "anti-Xa activity", "property_key": "anti_xa_activity", "value": "700", "unit": "IU/mg", "value_reported": "700", "unit_reported": "IU/mg", "method": "Review", "method_detail": "specific anti-Xa activity ~700 anti-Xa U/mg (~7x that of LMWHs)", "conditions": "specific anti-Xa activity ~700 anti-Xa U/mg (~7x that of LMWHs)", "conditions_detail": "specific anti-Xa activity ~700 anti-Xa U/mg (~7x that of LMWHs)", "doi": "10.1093/eurheartj/ehl492", "source_url": "https://doi.org/10.1093/eurheartj/ehl492", "year": "2007", "confidence": "high", "comments": "\"The specific anti-Xa activity of fondaparinux is about seven-fold higher than that of LMWHs (about 700 anti-Xa U/ mg and 100 anti-Xa U/mg, respectively).\" — U/mg = IU/mg; ~700 U/mg corroborated by Gao 2024 (BMC Surgery) [De Caterina R, Husted S, Wallentin L, et al., 2007, confidence: high]" }, { "id": 747, "dataset": "heparin", "entity": "fondaparinux", "entity_group": "", "entity_class": "synthetic", "property": "anti-IIa activity", "property_key": "anti_iia_activity", "value": "0", "unit": "IU/mg", "value_reported": "0", "unit_reported": "IU/mg", "method": "Review", "method_detail": "no anti-IIa (anti-thrombin) activity; selective Factor Xa inhibitor", "conditions": "no anti-IIa (anti-thrombin) activity; selective Factor Xa inhibitor", "conditions_detail": "no anti-IIa (anti-thrombin) activity; selective Factor Xa inhibitor", "doi": "10.1186/1477-9560-9-5", "source_url": "https://doi.org/10.1186/1477-9560-9-5", "year": "2011", "confidence": "high", "comments": "\"Fondaparinux cannot inhibit thrombin and its anticoagulant activity is entirely dependent on its ability to selectively inhibit Factor Xa\" — Qualitative: anti-IIa activity is effectively zero (cannot inhibit thrombin/factor IIa) [Fareed J, Adiguzel C, Thethi I, 2011, confidence: high]" }, { "id": 748, "dataset": "heparin", "entity": "fondaparinux", "entity_group": "", "entity_class": "synthetic", "property": "anti-Xa activity", "property_key": "anti_xa_activity", "value": "700", "unit": "IU/mg", "value_reported": "700", "unit_reported": "IU/mg", "method": "Review", "method_detail": "specific anti-Xa activity ~700 units/mg (vs ~100 units/mg for LMWHs)", "conditions": "specific anti-Xa activity ~700 units/mg (vs ~100 units/mg for LMWHs)", "conditions_detail": "specific anti-Xa activity ~700 units/mg (vs ~100 units/mg for LMWHs)", "doi": "10.1186/s12893-024-02440-0", "source_url": "https://doi.org/10.1186/s12893-024-02440-0", "year": "2024", "confidence": "high", "comments": "\"fondaparinux sodium has been reported to have higher specific anti-Xa activity than LMWHs (approximately 700 units/mg and 100 units/mg, respectively)\" — Independent corroboration of De Caterina 2007 value [Gao X, Jin X, Huang R, et al., 2024, confidence: high]" }, { "id": 749, "dataset": "heparin", "entity": "fondaparinux", "entity_group": "", "entity_class": "synthetic", "property": "molecular weight", "property_key": "molecular_weight", "value": "1.728", "unit": "kDa", "value_reported": "1728", "unit_reported": "Da", "method": "Review", "method_detail": "molecular weight 1728 Da (ultralow-molecular-weight heparin / synthetic pentasaccharide)", "conditions": "molecular weight 1728 Da (ultralow-molecular-weight heparin / synthetic pentasaccharide)", "conditions_detail": "molecular weight 1728 Da (ultralow-molecular-weight heparin / synthetic pentasaccharide)", "doi": "10.1021/jacsau.2c00537", "source_url": "https://doi.org/10.1021/jacsau.2c00537", "year": "2022", "confidence": "high", "comments": "\"ultralow-molecular weight heparin (UMWH, molecular weight 1500–3000 Da) such as synthetic pentasaccharide fondaparinux (molecular weight 1728 Da).\" — Also gives UFH ~16000 Da and LMWH 3500-6000 Da in same sentence [Zhang L, Liu Y, Xu Z, et al., 2022, confidence: high]" }, { "id": 750, "dataset": "heparin", "entity": "danaparoid", "entity_group": "", "entity_class": "heparinoid (other)", "property": "molecular weight", "property_key": "molecular_weight", "value": "4.4", "unit": "kDa", "value_reported": "4200-4600", "unit_reported": "Da", "method": "Experiment", "method_detail": "weight-average molecular weight (Mw) by HP-SEC-TDA of danaparoid API samples", "conditions": "weight-average molecular weight (Mw) by HP-SEC-TDA of danaparoid API samples", "conditions_detail": "weight-average molecular weight (Mw) by HP-SEC-TDA of danaparoid API samples | Mn Da: 3300-3400 | polydispersity: 1.27-1.36", "doi": "10.3390/molecules22071116", "source_url": "https://doi.org/10.3390/molecules22071116", "year": "2017", "confidence": "high", "comments": "\"Danaparoid was a low-molecular-weight mixture of HS, CS, and DS, confirmed by experimental weight average molecular weight (Mw) ranging from 4200 to 4600 Da.\" — Mn 3300-3400 Da; mixture of heparan sulfate, dermatan sulfate, chondroitin sulfate [Gardini C, Urso E, Guerrini M, et al., 2017, confidence: high]" }, { "id": 751, "dataset": "heparin", "entity": "danaparoid", "entity_group": "", "entity_class": "heparinoid (other)", "property": "anti-Xa/IIa ratio", "property_key": "anti_xa_iia_ratio", "value": "> UFH", "unit": "ratio", "value_reported": "> UFH", "unit_reported": "ratio", "method": "Review", "method_detail": "anti-factor Xa/IIa ratio greater than that of unfractionated heparin (qualitative)", "conditions": "anti-factor Xa/IIa ratio greater than that of unfractionated heparin (qualitative)", "conditions_detail": "anti-factor Xa/IIa ratio greater than that of unfractionated heparin (qualitative)", "doi": "10.1186/cc6119", "source_url": "https://doi.org/10.1186/cc6119", "year": "2007", "confidence": "medium", "comments": "\"Danaparoid is a low-molecular-weight heparinoid consisting of a mixture of heparan sulphate (84%), dermatan sulphate (12%), and small amounts of chondroitin sulphate (4%). Its pharmacological effect is exerted primarily by the inhibition of factors Xa and IIa at a ratio greater than that of unfractionated heparin\" — Qualitative ratio only; danaparoid composition: 84% HS, 12% DS, 4% CS [de Pont AC, Hofstra JJ, Pik DR, et al., 2007, confidence: medium]" }, { "id": 752, "dataset": "heparin", "entity": "danaparoid (heparan sulfate component)", "entity_group": "", "entity_class": "heparan sulfate", "property": "molecular weight", "property_key": "molecular_weight", "value": "3.4", "unit": "kDa", "value_reported": "3300-3500", "unit_reported": "Da", "method": "Experiment", "method_detail": "weight-average Mw of the heparan sulfate (HS) fraction isolated from danaparoid", "conditions": "weight-average Mw of the heparan sulfate (HS) fraction isolated from danaparoid", "conditions_detail": "weight-average Mw of the heparan sulfate (HS) fraction isolated from danaparoid | note: enriched HS fraction, CS/DS still present 5-14%", "doi": "10.3390/molecules22071116", "source_url": "https://doi.org/10.3390/molecules22071116", "year": "2017", "confidence": "high", "comments": "\"their weight average Mw was found in the range from 3300 to 3500 Da, consistent with SEC fractions data.\" — HS is the major component of danaparoid; LMW heparan sulfate [Gardini C, Urso E, Guerrini M, et al., 2017, confidence: high]" }, { "id": 753, "dataset": "heparin", "entity": "heparan sulfate", "entity_group": "", "entity_class": "heparan sulfate", "property": "molecular weight", "property_key": "molecular_weight", "value": "55", "unit": "kDa", "value_reported": "10-100", "unit_reported": "kDa", "method": "Review", "method_detail": "typical molecular mass range of heparan sulfate glycosaminoglycan chains", "conditions": "typical molecular mass range of heparan sulfate glycosaminoglycan chains", "conditions_detail": "typical molecular mass range of heparan sulfate glycosaminoglycan chains", "doi": "10.1074/jbc.m110.148874", "source_url": "https://doi.org/10.1074/jbc.m110.148874", "year": "2011", "confidence": "high", "comments": "\"These linear, sulfated glycosaminoglycans have molecular masses that typically range from 10 to 100 kDa (5).\" — native heparan sulfate (J Biol Chem) [Murali S, Leong DFM, Lee JJL, et al., 2011, confidence: high]" }, { "id": 754, "dataset": "heparin", "entity": "heparan sulfate", "entity_group": "", "entity_class": "heparan sulfate", "property": "molecular weight", "property_key": "molecular_weight", "value": "50", "unit": "kDa", "value_reported": "30-70", "unit_reported": "kDa", "method": "Review", "method_detail": "molecular weight of cell-surface heparan sulfate (40-300 sugar residues, ~20-150 nm long)", "conditions": "molecular weight of cell-surface heparan sulfate (40-300 sugar residues, ~20-150 nm long)", "conditions_detail": "molecular weight of cell-surface heparan sulfate (40-300 sugar residues, ~20-150 nm long)", "doi": "10.1128/jvi.02222-18", "source_url": "https://doi.org/10.1128/jvi.02222-18", "year": "2019", "confidence": "high", "comments": "\"Heparan sulfate is a 30-to 70-kDa linear polysaccharide (40 to 300 sugar residues and approximately 20 to 150 nm long) composed of alternating sulfated (NS) domains and unsulfated (NA) domains\" [Dhindwal S, Avila B, Feng S, et al., 2019, confidence: high]" }, { "id": 755, "dataset": "heparin", "entity": "heparan sulfate (male mouse liver)", "entity_group": "", "entity_class": "heparan sulfate", "property": "molecular weight", "property_key": "molecular_weight", "value": "100", "unit": "kDa", "value_reported": "100", "unit_reported": "kDa", "method": "Experiment", "method_detail": "HS chain length determined by molecular sieving (~100 kDa, 30-40 disaccharide repeats); male adult mouse liver", "conditions": "HS chain length determined by molecular sieving (~100 kDa, 30-40 disaccharide repeats); male adult mouse liver", "conditions_detail": "HS chain length determined by molecular sieving (~100 kDa, 30-40 disaccharide repeats); male adult mouse liver | source: male adult mouse liver | disaccharide repeats: 30-40", "doi": "10.1074/jbc.m110.148874", "source_url": "https://doi.org/10.1074/jbc.m110.148874", "year": "2011", "confidence": "high", "comments": "\"size determination showed that HS chain lengths were ~100 and ~22 kDa, comprising 30-40 and 6-8 disaccharide repeats, respectively.\" — male vs female liver HS [Murali S, Leong DFM, Lee JJL, et al., 2011, confidence: high]" }, { "id": 756, "dataset": "heparin", "entity": "heparan sulfate (female mouse liver)", "entity_group": "", "entity_class": "heparan sulfate", "property": "molecular weight", "property_key": "molecular_weight", "value": "22", "unit": "kDa", "value_reported": "22", "unit_reported": "kDa", "method": "Experiment", "method_detail": "HS chain length determined by molecular sieving (~22 kDa, 6-8 disaccharide repeats); female adult mouse liver", "conditions": "HS chain length determined by molecular sieving (~22 kDa, 6-8 disaccharide repeats); female adult mouse liver", "conditions_detail": "HS chain length determined by molecular sieving (~22 kDa, 6-8 disaccharide repeats); female adult mouse liver | source: female adult mouse liver | disaccharide repeats: 6-8", "doi": "10.1074/jbc.m110.148874", "source_url": "https://doi.org/10.1074/jbc.m110.148874", "year": "2011", "confidence": "high", "comments": "\"size determination showed that HS chain lengths were ~100 and ~22 kDa, comprising 30-40 and 6-8 disaccharide repeats, respectively.\" [Murali S, Leong DFM, Lee JJL, et al., 2011, confidence: high]" }, { "id": 757, "dataset": "heparin", "entity": "heparan sulfate (CHO cell, nascent)", "entity_group": "", "entity_class": "heparan sulfate", "property": "molecular weight", "property_key": "molecular_weight", "value": "81", "unit": "kDa", "value_reported": "81", "unit_reported": "kDa", "method": "Experiment", "method_detail": "nascent CHO cell heparan sulfate chains, ~370 residues long (81 kDa)", "conditions": "nascent CHO cell heparan sulfate chains, ~370 residues long (81 kDa)", "conditions_detail": "nascent CHO cell heparan sulfate chains, ~370 residues long (81 kDa) | source: Chinese hamster ovary (CHO) cell | residues: 370", "doi": "10.1074/jbc.272.14.9078", "source_url": "https://doi.org/10.1074/jbc.272.14.9078", "year": "1997", "confidence": "high", "comments": "\"Nascent CHO HS chains are on average 370 residues long, as estimated from their molecular mass (81 kDa) and average sugar unit mass (220 Da).\" [Tumova S, Bame KJ, 1997, confidence: high]" }, { "id": 758, "dataset": "heparin", "entity": "heparan sulfate (bovine vitreous humour)", "entity_group": "", "entity_class": "heparan sulfate", "property": "molecular weight", "property_key": "molecular_weight", "value": "204", "unit": "kDa", "value_reported": "204", "unit_reported": "kDa", "method": "Experiment", "method_detail": "average molecular weight of heparan sulfate from bovine eye vitreous humour", "conditions": "average molecular weight of heparan sulfate from bovine eye vitreous humour", "conditions_detail": "average molecular weight of heparan sulfate from bovine eye vitreous humour | source: bovine eye vitreous humour", "doi": "10.1007/s10719-017-9808-1", "source_url": "https://doi.org/10.1007/s10719-017-9808-1", "year": "2018", "confidence": "high", "comments": "\"The average molecular weights of CS and HS were 148 kDa and 204 kDa, respectively.\" — tissue-derived HS; high MW [Peng Y, Yu Y, Lin L, et al., 2018, confidence: high]" }, { "id": 759, "dataset": "heparin", "entity": "heparin oligosaccharide (18-mer / minimum thrombin-bridging chain)", "entity_group": "", "entity_class": "heparin oligosaccharide", "property": "molecular weight", "property_key": "molecular_weight", "value": "5.4", "unit": "kDa", "value_reported": "5400", "unit_reported": "Da", "method": "Review", "method_detail": "molecular weight of the 18-saccharide chain required for thrombin (anti-IIa) potentiation", "conditions": "molecular weight of the 18-saccharide chain required for thrombin (anti-IIa) potentiation", "conditions_detail": "molecular weight of the 18-saccharide chain required for thrombin (anti-IIa) potentiation | saccharides: 18", "doi": "10.1124/pharmrev.122.000684", "source_url": "https://doi.org/10.1124/pharmrev.122.000684", "year": "2023", "confidence": "high", "comments": "\"The 18 saccharides required for thrombin-AT potentiation equates to 5400 daltons in weight and explains some of the differences in anti-Xa and anti-IIa activity of low molecular weight heparins\" — Chains <5400 Da have anti-Xa activity only; mechanistic threshold [Hogwood J, Mulloy B, Lever R, Gray E, Page CP, 2023, confidence: high]" }, { "id": 760, "dataset": "heparin", "entity": "heparin pentasaccharide (AT-binding A-domain)", "entity_group": "", "entity_class": "heparin oligosaccharide", "property": "molecular weight", "property_key": "molecular_weight", "value": "1.7", "unit": "kDa", "value_reported": "1700", "unit_reported": "Da", "method": "Experiment", "method_detail": "molecular weight of the minimum antithrombin-binding pentasaccharide (lower bound of MW series studied)", "conditions": "molecular weight of the minimum antithrombin-binding pentasaccharide (lower bound of MW series studied)", "conditions_detail": "molecular weight of the minimum antithrombin-binding pentasaccharide (lower bound of MW series studied)", "doi": "10.1046/j.1538-7836.2003.00211.x", "source_url": "https://doi.org/10.1046/j.1538-7836.2003.00211.x", "year": "2003", "confidence": "high", "comments": "\"10 heparins with molecular weights ranging from 1700 (pentasaccharide) to 20 000\" — natural pentasaccharide ~1700 Da (cf. synthetic fondaparinux 1728 Da) [Al Dieri R, Wagenvoord R, van Dedem GWK, et al., 2003, confidence: high]" } ] }