Glyco Property List

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{
    "count": 839,
    "next": "http://glycodata.org/api/gdd/glyco-properties/?format=api&page=32",
    "previous": "http://glycodata.org/api/gdd/glyco-properties/?format=api&page=30",
    "results": [
        {
            "id": 601,
            "dataset": "cellulose",
            "entity": "regenerated cellulose fiber (lyocell)",
            "entity_group": "lyocell/Tencel",
            "entity_class": "regenerated cellulose",
            "property": "glass transition temperature",
            "property_key": "Tg",
            "value": "239.85",
            "unit": "C",
            "value_reported": "513",
            "unit_reported": "K",
            "method": "Experiment",
            "method_detail": "DMA; Tg of dry fiber from tan delta; water plasticizes Tg to room temperature at water regain ~56%",
            "conditions": "DMA; Tg of dry fiber from tan delta; water plasticizes Tg to room temperature at water regain ~56%",
            "conditions_detail": "DMA; Tg of dry fiber from tan delta; water plasticizes Tg to room temperature at water regain ~56% | test state: dry | water (wt%): 0",
            "doi": "10.1016/j.carbpol.2019.115663",
            "source_url": "https://doi.org/10.1016/j.carbpol.2019.115663",
            "year": "2020",
            "confidence": "medium",
            "comments": "\"The glass transition temperature (Tg) of dry regenerated cellulose is 552 K for rayon, 523 K for cupra, and 513 K for lyocell\"  — Dry lyocell regenerated cellulose Tg = 513 K (DMA). Tg falls to room temperature at ~56% water regain. Cellulose II.  [Okugawa A, Sakaino M, Yuguchi Y, et al., 2020, confidence: medium]"
        },
        {
            "id": 602,
            "dataset": "cellulose",
            "entity": "regenerated cellulose film (dry)",
            "entity_group": "regenerated cellulose (other)",
            "entity_class": "regenerated cellulose",
            "property": "glass transition temperature",
            "property_key": "Tg",
            "value": "126.85",
            "unit": "C",
            "value_reported": "400",
            "unit_reported": "K",
            "method": "Review",
            "method_detail": "linear dilatometry of dry regenerated-cellulose film; alpha2 secondary glass transition near 400 K (390-410 K) and beta transition near 280-300 K",
            "conditions": "linear dilatometry of dry regenerated-cellulose film; alpha2 secondary glass transition near 400 K (390-410 K) and beta transition near 280-300 K",
            "conditions_detail": "linear dilatometry of dry regenerated-cellulose film; alpha2 secondary glass transition near 400 K (390-410 K) and beta transition near 280-300 K | test state: dry | water (wt%): 0",
            "doi": "10.30958/ajs.3-4-4",
            "source_url": "https://www.athensjournals.gr/sciences/2016-3-4-4-Ioelovich.pdf",
            "year": "2016",
            "confidence": "low",
            "comments": "\"Figure 3. Linear Dilatometry of Dry Film of Regenerated Cellulose ... the temperatures 390-410 K, the alpha2-relaxation transition was discovered ... The third relaxation transition was detected at the temperatures 280-300 K (beta).\"  — Dry regenerated-cellulose film dilatometry shows alpha2 secondary glass transition ~390-410 K (value 400 K) and beta ~280-300 K. Cellulose II. Estimate from dilatometry inflection.  [Ioelovich M, 2016, confidence: low]"
        },
        {
            "id": 603,
            "dataset": "cellulose",
            "entity": "CNC-doped cellulose triacetate (TAC) optical film",
            "entity_group": "cellulose acetate",
            "entity_class": "nanocellulose",
            "property": "glass transition temperature",
            "property_key": "Tg",
            "value": "215.5",
            "unit": "C",
            "value_reported": "215-216",
            "unit_reported": "C",
            "method": "Experiment",
            "method_detail": "glass transition temperature of CNC-doped cellulose triacetate films (TAC-X, 0-2 wt% CNC); thermal characterization (DSC/TGA)",
            "conditions": "glass transition temperature of CNC-doped cellulose triacetate films (TAC-X, 0-2 wt% CNC); thermal characterization (DSC/TGA)",
            "conditions_detail": "glass transition temperature of CNC-doped cellulose triacetate films (TAC-X, 0-2 wt% CNC); thermal characterization (DSC/TGA) | test state: cast nanocomposite film",
            "doi": "10.1002/slct.202400262",
            "source_url": "https://doi.org/10.1002/slct.202400262",
            "year": "2024",
            "confidence": "medium",
            "comments": "\"its glass transition temperature and maximum decomposition temperature falling between 215-216 °C and 366-368 °C respectively.\"  — Matrix is cellulose triacetate (a cellulose derivative) doped with up to 2 wt% CNC; Tg essentially that of the TAC phase, nearly unchanged by CNC. Both components cellulosic.  [Zhou Y, Tang S, Zhang Q, Tan L, et al., 2024, confidence: medium]"
        },
        {
            "id": 604,
            "dataset": "cellulose",
            "entity": "microcrystalline cellulose (dehydrated)",
            "entity_group": "microcrystalline cellulose (MCC)",
            "entity_class": "pulp / microcrystalline cellulose",
            "property": "glass transition temperature",
            "property_key": "Tg",
            "value": "84.0",
            "unit": "C",
            "value_reported": "84",
            "unit_reported": "C",
            "method": "Experiment",
            "method_detail": "DSC, heat-capacity step on reheat after 4 consecutive dehydration cycles, dry (anhydrous) cellulose; delta-Cp = 0.30 ± 0.01 J/(g·C)",
            "conditions": "DSC, heat-capacity step on reheat after 4 consecutive dehydration cycles, dry (anhydrous) cellulose; delta-Cp = 0.30 ± 0.01 J/(g·C)",
            "conditions_detail": "DSC, heat-capacity step on reheat after 4 consecutive dehydration cycles, dry (anhydrous) cellulose; delta-Cp = 0.30 ± 0.01 J/(g·C) | heating rate (K/min): 20 | test state: dehydrated microcrystalline cellulose | water (wt%): 0",
            "doi": "10.1088/0022-3727/44/4/045403",
            "source_url": "https://hal.science/hal-00589771",
            "year": "2011",
            "confidence": "high",
            "comments": "\"The Tg of dehydrated cellulose is found at 84 ± 1°C with a delta-Cp = 0.30 ± 0.01 J/(g.°C).\"  — Microcrystalline cellulose powder/pellets, fully dehydrated. Tg decreases strongly with hydration; hydrated runs (0-5% water) recorded at 20 C/min. Green OA via HAL.  [Roig F, Dantras E, Dandurand J, Lacabanne C, 2011, confidence: high]"
        },
        {
            "id": 605,
            "dataset": "cellulose",
            "entity": "cellulose (dry ball-milled wood pulp; eucalyptus/softwood)",
            "entity_group": "dissolving/wood pulp",
            "entity_class": "pulp / microcrystalline cellulose",
            "property": "glass transition temperature",
            "property_key": "Tg",
            "value": "204.85",
            "unit": "C",
            "value_reported": "478",
            "unit_reported": "K",
            "method": "Model",
            "method_detail": "DMA 'pocket' technique on water-content series; dry-cellulose Tg by Couchman-Karasz extrapolation to 0% water",
            "conditions": "DMA 'pocket' technique on water-content series; dry-cellulose Tg by Couchman-Karasz extrapolation to 0% water",
            "conditions_detail": "DMA 'pocket' technique on water-content series; dry-cellulose Tg by Couchman-Karasz extrapolation to 0% water | test state: dry ball-milled cellulose (extrapolated) | water (wt%): 0",
            "doi": "10.1007/s10570-010-9425-7",
            "source_url": "https://doi.org/10.1007/s10570-010-9425-7",
            "year": "2010",
            "confidence": "medium",
            "comments": "\"Fitting the data to a Couchman-Karasz relationship predicted a value for Tg of the dry cellulose of approximately 478 K, which was similar to values previously reported for other dry polysaccharides.\"  — Model extrapolation (Couchman-Karasz) of water-content-dependent DMA transition to dry state; measured over 5-42% db water. Pulp source. (Same study as the native-cellulose 478 K record; listed under pulp/MCC for the pulp framing.)  [Paes SS, Sun S, MacNaughtan W, Ibbett R, Ganster J, Foster TJ, Mitchell JR, 2010, confidence: medium]"
        },
        {
            "id": 606,
            "dataset": "cellulose",
            "entity": "amorphous region of cellulose (dry)",
            "entity_group": "cellulose (generic)",
            "entity_class": "pulp / microcrystalline cellulose",
            "property": "glass transition temperature",
            "property_key": "Tg",
            "value": "225.0",
            "unit": "C",
            "value_reported": "200-250",
            "unit_reported": "C",
            "method": "Review",
            "method_detail": "Literature compilation (citing Back and Salmen 1982) of dry-state softening/glass transition ranges for wood polymers",
            "conditions": "Literature compilation (citing Back and Salmen 1982) of dry-state softening/glass transition ranges for wood polymers",
            "conditions_detail": "Literature compilation (citing Back and Salmen 1982) of dry-state softening/glass transition ranges for wood polymers | test state: dry amorphous cellulose | water (wt%): 0",
            "doi": "10.15376/biores.6.2.2125-2134",
            "source_url": "https://doi.org/10.15376/biores.6.2.2125-2134",
            "year": "2011",
            "confidence": "high",
            "comments": "\"When dry, the differences in glass transition temperature are not huge: 200 to 250 °C for the amorphous region of cellulose, 150 to 220 °C for hemicelluloses, and 205 °C for lignin (Back and Salmén 1982).\"  — Review/compilation value for canonical dry amorphous-cellulose Tg range. At water-saturated conditions Tg drops to subambient. (Duplicate framing of the native-cellulose record; pulp/wood context.)  [Horvath B, Peralta PN, Frazier CE, Peszlen I, 2011, confidence: high]"
        },
        {
            "id": 607,
            "dataset": "heparin",
            "entity": "heparin (UFH) - porcine mucosal",
            "entity_group": "",
            "entity_class": "heparin (UFH)",
            "property": "anti-IIa activity",
            "property_key": "anti_iia_activity",
            "value": "183.4",
            "unit": "IU/mg",
            "value_reported": "183.4",
            "unit_reported": "IU/mg",
            "method": "Experiment",
            "method_detail": "antithrombin-dependent anti-IIa (AT:aIIa) amidolytic assay vs USP heparin reference standard",
            "conditions": "antithrombin-dependent anti-IIa (AT:aIIa) amidolytic assay vs USP heparin reference standard",
            "conditions_detail": "antithrombin-dependent anti-IIa (AT:aIIa) amidolytic assay vs USP heparin reference standard | source species: porcine intestinal mucosa | assay: AT-dependent amidolytic | uncertainty: +/-1.7 SD",
            "doi": "10.3389/fmed.2018.00360",
            "source_url": "https://doi.org/10.3389/fmed.2018.00360",
            "year": "2019",
            "confidence": "high",
            "comments": "\"Porcine heparins exhibited mean anti-Xa and anti-IIa potencies of 184.6 +/- 2.8 and 183.4 +/- 1.7 U/mg, respectively.\"  — Directly-stated anti-IIa specific activity for porcine mucosal heparin API.  [Jeske W, Kouta A, Farooqui A, et al., 2019, confidence: high]"
        },
        {
            "id": 608,
            "dataset": "heparin",
            "entity": "heparin (UFH) - bovine mucosal",
            "entity_group": "",
            "entity_class": "heparin (UFH)",
            "property": "anti-IIa activity",
            "property_key": "anti_iia_activity",
            "value": "133",
            "unit": "IU/mg",
            "value_reported": "133.0",
            "unit_reported": "IU/mg",
            "method": "Experiment",
            "method_detail": "antithrombin-dependent anti-IIa (AT:aIIa) amidolytic assay vs USP heparin reference standard",
            "conditions": "antithrombin-dependent anti-IIa (AT:aIIa) amidolytic assay vs USP heparin reference standard",
            "conditions_detail": "antithrombin-dependent anti-IIa (AT:aIIa) amidolytic assay vs USP heparin reference standard | source species: bovine intestinal mucosa | assay: AT-dependent amidolytic | uncertainty: +/-7.5 SD",
            "doi": "10.3389/fmed.2018.00360",
            "source_url": "https://doi.org/10.3389/fmed.2018.00360",
            "year": "2019",
            "confidence": "high",
            "comments": "\"The potencies of bovine heparin were significantly lower at 132.4 +/- 5.0 and 133.0 +/- 7.5, respectively, based on anti-Xa and anti-IIa activity (p = 0.003 for anti-Xa and anti-IIa, Mann-Whitney test).\"  — Directly-stated anti-IIa specific activity for bovine mucosal heparin API; lower than porcine.  [Jeske W, Kouta A, Farooqui A, et al., 2019, confidence: high]"
        },
        {
            "id": 609,
            "dataset": "heparin",
            "entity": "heparin (UFH) - porcine mucosal",
            "entity_group": "",
            "entity_class": "heparin (UFH)",
            "property": "anti-IIa activity",
            "property_key": "anti_iia_activity",
            "value": "107",
            "unit": "IU/mg",
            "value_reported": "107",
            "unit_reported": "IU/mg",
            "method": "Experiment",
            "method_detail": "antithrombin-dependent anti-IIa (AT:aIIa) potency vs 6th International Standard for UFH, parallel-line bioassay",
            "conditions": "antithrombin-dependent anti-IIa (AT:aIIa) potency vs 6th International Standard for UFH, parallel-line bioassay",
            "conditions_detail": "antithrombin-dependent anti-IIa (AT:aIIa) potency vs 6th International Standard for UFH, parallel-line bioassay | source species: porcine intestinal mucosa | assay: AT-dependent anti-IIa | standard: 6th International Standard for UFH",
            "doi": "10.3390/ph10030059",
            "source_url": "https://doi.org/10.3390/ph10030059",
            "year": "2017",
            "confidence": "high",
            "comments": "\"AT:aIIa potencies (107 IU/mg) were lower and the HCII:aIIa activities (165 IU/mg) were higher than AT:aXa and APTT estimates.\"  — AT-dependent anti-IIa potency (porcine heparin); contrasts with the higher HC-II-dependent value below.  [Hogwood J, Mulloy B, Gray E, 2017, confidence: high]"
        },
        {
            "id": 610,
            "dataset": "heparin",
            "entity": "heparin (UFH) - porcine mucosal",
            "entity_group": "",
            "entity_class": "heparin (UFH)",
            "property": "anti-IIa activity",
            "property_key": "anti_iia_activity",
            "value": "165",
            "unit": "IU/mg",
            "value_reported": "165",
            "unit_reported": "IU/mg",
            "method": "Experiment",
            "method_detail": "heparin cofactor II-dependent anti-IIa (HCII:aIIa) potency vs 6th International Standard for UFH",
            "conditions": "heparin cofactor II-dependent anti-IIa (HCII:aIIa) potency vs 6th International Standard for UFH",
            "conditions_detail": "heparin cofactor II-dependent anti-IIa (HCII:aIIa) potency vs 6th International Standard for UFH | source species: porcine intestinal mucosa | assay: HC-II-dependent anti-IIa | standard: 6th International Standard for UFH",
            "doi": "10.3390/ph10030059",
            "source_url": "https://doi.org/10.3390/ph10030059",
            "year": "2017",
            "confidence": "high",
            "comments": "\"AT:aIIa potencies (107 IU/mg) were lower and the HCII:aIIa activities (165 IU/mg) were higher than AT:aXa and APTT estimates.\"  — Heparin cofactor II-dependent anti-IIa potency (porcine heparin).  [Hogwood J, Mulloy B, Gray E, 2017, confidence: high]"
        },
        {
            "id": 611,
            "dataset": "heparin",
            "entity": "heparin (UFH) - bovine lung",
            "entity_group": "",
            "entity_class": "heparin (UFH)",
            "property": "anti-IIa activity",
            "property_key": "anti_iia_activity",
            "value": "127",
            "unit": "IU/mg",
            "value_reported": "127",
            "unit_reported": "IU/mg",
            "method": "Experiment",
            "method_detail": "antithrombin-dependent anti-IIa (AT:aIIa) potency, mean of ten batches vs 6th International Standard for UFH",
            "conditions": "antithrombin-dependent anti-IIa (AT:aIIa) potency, mean of ten batches vs 6th International Standard for UFH",
            "conditions_detail": "antithrombin-dependent anti-IIa (AT:aIIa) potency, mean of ten batches vs 6th International Standard for UFH | source species: bovine lung | assay: AT-dependent anti-IIa | n batches: 10",
            "doi": "10.3390/ph10030059",
            "source_url": "https://doi.org/10.3390/ph10030059",
            "year": "2017",
            "confidence": "high",
            "comments": "\"For ten batches of bovine lung heparin, the AT:aXa, AT:aIIa and APTT (130, 127, 121 IU/mg respectively) activities were similar (ANOVA, p > 0.01), but HCII:aIIa (220 IU/mg) activity was significantly higher than all other activities (ANOVA, p < 0.0001).\"  — AT-dependent anti-IIa for bovine lung heparin.  [Hogwood J, Mulloy B, Gray E, 2017, confidence: high]"
        },
        {
            "id": 612,
            "dataset": "heparin",
            "entity": "heparin (UFH) - bovine lung",
            "entity_group": "",
            "entity_class": "heparin (UFH)",
            "property": "anti-IIa activity",
            "property_key": "anti_iia_activity",
            "value": "220",
            "unit": "IU/mg",
            "value_reported": "220",
            "unit_reported": "IU/mg",
            "method": "Experiment",
            "method_detail": "heparin cofactor II-dependent anti-IIa (HCII:aIIa) potency, mean of ten batches vs 6th International Standard for UFH",
            "conditions": "heparin cofactor II-dependent anti-IIa (HCII:aIIa) potency, mean of ten batches vs 6th International Standard for UFH",
            "conditions_detail": "heparin cofactor II-dependent anti-IIa (HCII:aIIa) potency, mean of ten batches vs 6th International Standard for UFH | source species: bovine lung | assay: HC-II-dependent anti-IIa | n batches: 10",
            "doi": "10.3390/ph10030059",
            "source_url": "https://doi.org/10.3390/ph10030059",
            "year": "2017",
            "confidence": "high",
            "comments": "\"but HCII:aIIa (220 IU/mg) activity was significantly higher than all other activities (ANOVA, p < 0.0001).\"  — Heparin cofactor II-dependent anti-IIa for bovine lung heparin.  [Hogwood J, Mulloy B, Gray E, 2017, confidence: high]"
        },
        {
            "id": 613,
            "dataset": "heparin",
            "entity": "rdLMWH-1 (rationally designed LMWH)",
            "entity_group": "",
            "entity_class": "LMWH",
            "property": "anti-IIa activity",
            "property_key": "anti_iia_activity",
            "value": "230",
            "unit": "IU/mg",
            "value_reported": "230",
            "unit_reported": "IU/mg",
            "method": "Experiment",
            "method_detail": "anti-IIa amidolytic activity of a rationally designed (enzymatically depolymerized) LMWH",
            "conditions": "anti-IIa amidolytic activity of a rationally designed (enzymatically depolymerized) LMWH",
            "conditions_detail": "anti-IIa amidolytic activity of a rationally designed (enzymatically depolymerized) LMWH | product: designer LMWH, not a marketed product",
            "doi": "10.1073/pnas.252643299",
            "source_url": "https://doi.org/10.1073/pnas.252643299",
            "year": "2003",
            "confidence": "high",
            "comments": "\"rdLMWH-1 and -2 possessed significant anti-IIa activities of 230 IU/mg and 155 IU/mg, respectively.\"  — Engineered LMWH with unusually high anti-IIa; included for range context (not a commercial product).  [Sundaram M, Qi Y, Shriver Z, et al., 2003, confidence: high]"
        },
        {
            "id": 614,
            "dataset": "heparin",
            "entity": "rdLMWH-2 (rationally designed LMWH)",
            "entity_group": "",
            "entity_class": "LMWH",
            "property": "anti-IIa activity",
            "property_key": "anti_iia_activity",
            "value": "155",
            "unit": "IU/mg",
            "value_reported": "155",
            "unit_reported": "IU/mg",
            "method": "Experiment",
            "method_detail": "anti-IIa amidolytic activity of a rationally designed (enzymatically depolymerized) LMWH",
            "conditions": "anti-IIa amidolytic activity of a rationally designed (enzymatically depolymerized) LMWH",
            "conditions_detail": "anti-IIa amidolytic activity of a rationally designed (enzymatically depolymerized) LMWH | product: designer LMWH, not a marketed product",
            "doi": "10.1073/pnas.252643299",
            "source_url": "https://doi.org/10.1073/pnas.252643299",
            "year": "2003",
            "confidence": "high",
            "comments": "\"rdLMWH-1 and -2 possessed significant anti-IIa activities of 230 IU/mg and 155 IU/mg, respectively.\"  — Engineered LMWH; included for range context (not a commercial product).  [Sundaram M, Qi Y, Shriver Z, et al., 2003, confidence: high]"
        },
        {
            "id": 615,
            "dataset": "heparin",
            "entity": "fondaparinux",
            "entity_group": "",
            "entity_class": "synthetic",
            "property": "anti-IIa activity",
            "property_key": "anti_iia_activity",
            "value": "0",
            "unit": "IU/mg",
            "value_reported": "0",
            "unit_reported": "IU/mg",
            "method": "Review",
            "method_detail": "synthetic pentasaccharide; selectively inhibits factor Xa only, no anti-IIa (thrombin) activity",
            "conditions": "synthetic pentasaccharide; selectively inhibits factor Xa only, no anti-IIa (thrombin) activity",
            "conditions_detail": "synthetic pentasaccharide; selectively inhibits factor Xa only, no anti-IIa (thrombin) activity | mechanism: too short to bridge antithrombin and thrombin",
            "doi": "10.3390/ph16040584",
            "source_url": "https://doi.org/10.3390/ph16040584",
            "year": "2023",
            "confidence": "medium",
            "comments": "\"Conversely, inhibition of FXa requires only the binding of the pentasaccharide to AT-III, without the requirement for FXa to also bind to heparin. LMW heparins therefore have greater anti-Xa activity than anti-IIa activity.\"  — Fondaparinux (pentasaccharide) is too short to form the ternary anti-IIa bridge, so anti-IIa = 0; corroborates existing record.  [Shute JK, 2023, confidence: medium]"
        },
        {
            "id": 616,
            "dataset": "heparin",
            "entity": "heparin (UFH)",
            "entity_group": "",
            "entity_class": "heparin (UFH)",
            "property": "anti-Xa activity",
            "property_key": "anti_xa_activity",
            "value": "200",
            "unit": "IU/mg",
            "value_reported": "180-220",
            "unit_reported": "IU/mg",
            "method": "Review",
            "method_detail": "specific activity of current pharmaceutical UFH preparations",
            "conditions": "specific activity of current pharmaceutical UFH preparations",
            "conditions_detail": "specific activity of current pharmaceutical UFH preparations | avg MW Da: 13000-15000",
            "doi": "10.3390/ph16040584",
            "source_url": "https://doi.org/10.3390/ph16040584",
            "year": "2023",
            "confidence": "high",
            "comments": "\"Current pharmaceutical preparations of UFH have an average molecular weight of about 13,000-15,000 Da and specific activity of 180-220 International Units (IU)/mg.\"  — Specific activity range; in heparin standardization anti-Xa and total potency are closely matched for UFH (~1:1 anti-Xa:anti-IIa).  [Shute JK, 2023, confidence: high]"
        },
        {
            "id": 617,
            "dataset": "heparin",
            "entity": "heparin (UFH) - porcine mucosal",
            "entity_group": "",
            "entity_class": "heparin (UFH)",
            "property": "anti-Xa activity",
            "property_key": "anti_xa_activity",
            "value": "184.6",
            "unit": "IU/mg",
            "value_reported": "184.6",
            "unit_reported": "IU/mg",
            "method": "Experiment",
            "method_detail": "antithrombin-dependent anti-Xa (AT:aXa) amidolytic assay vs USP heparin reference standard",
            "conditions": "antithrombin-dependent anti-Xa (AT:aXa) amidolytic assay vs USP heparin reference standard",
            "conditions_detail": "antithrombin-dependent anti-Xa (AT:aXa) amidolytic assay vs USP heparin reference standard | source species: porcine intestinal mucosa | uncertainty: +/-2.8 SD",
            "doi": "10.3389/fmed.2018.00360",
            "source_url": "https://doi.org/10.3389/fmed.2018.00360",
            "year": "2019",
            "confidence": "high",
            "comments": "\"Porcine heparins exhibited mean anti-Xa and anti-IIa potencies of 184.6 +/- 2.8 and 183.4 +/- 1.7 U/mg, respectively.\"  — Companion anti-Xa value to the porcine anti-IIa record above.  [Jeske W, Kouta A, Farooqui A, et al., 2019, confidence: high]"
        },
        {
            "id": 618,
            "dataset": "heparin",
            "entity": "heparin (UFH) - bovine lung",
            "entity_group": "",
            "entity_class": "heparin (UFH)",
            "property": "anti-Xa activity",
            "property_key": "anti_xa_activity",
            "value": "130",
            "unit": "IU/mg",
            "value_reported": "130",
            "unit_reported": "IU/mg",
            "method": "Experiment",
            "method_detail": "antithrombin-dependent anti-Xa (AT:aXa) potency, mean of ten batches vs 6th International Standard for UFH",
            "conditions": "antithrombin-dependent anti-Xa (AT:aXa) potency, mean of ten batches vs 6th International Standard for UFH",
            "conditions_detail": "antithrombin-dependent anti-Xa (AT:aXa) potency, mean of ten batches vs 6th International Standard for UFH | source species: bovine lung | n batches: 10",
            "doi": "10.3390/ph10030059",
            "source_url": "https://doi.org/10.3390/ph10030059",
            "year": "2017",
            "confidence": "high",
            "comments": "\"For ten batches of bovine lung heparin, the AT:aXa, AT:aIIa and APTT (130, 127, 121 IU/mg respectively) activities were similar (ANOVA, p > 0.01)\"  — Bovine lung heparin anti-Xa potency.  [Hogwood J, Mulloy B, Gray E, 2017, confidence: high]"
        },
        {
            "id": 619,
            "dataset": "heparin",
            "entity": "heparin (UFH) - chicken intestinal",
            "entity_group": "",
            "entity_class": "heparin (UFH)",
            "property": "anti-Xa activity",
            "property_key": "anti_xa_activity",
            "value": "111",
            "unit": "IU/mg",
            "value_reported": "111",
            "unit_reported": "IU/mg",
            "method": "Review",
            "method_detail": "specific anti-Xa activity of heparin extracted from chicken intestine",
            "conditions": "specific anti-Xa activity of heparin extracted from chicken intestine",
            "conditions_detail": "specific anti-Xa activity of heparin extracted from chicken intestine | source species: chicken intestine | S C ratio: 2.26",
            "doi": "10.3390/molecules22061025",
            "source_url": "https://doi.org/10.3390/molecules22061025",
            "year": "2017",
            "confidence": "high",
            "comments": "\"Active heparin can be derived from chicken intestines with a specific aXa activity of 111 IU/mg and slightly lower degree of sulfation compared to porcine heparin produced according to the same method (S/C ratio resp.: 2.26 and 2.40).\"  — Non-mammalian (avian) heparin anti-Xa specific activity.  [van der Meer JY, Kellenbach E, van den Bos L, 2017, confidence: high]"
        },
        {
            "id": 620,
            "dataset": "heparin",
            "entity": "nadroparin",
            "entity_group": "",
            "entity_class": "LMWH",
            "property": "anti-Xa activity",
            "property_key": "anti_xa_activity",
            "value": "112.5",
            "unit": "IU/mg",
            "value_reported": "95-130",
            "unit_reported": "IU/mg",
            "method": "Review",
            "method_detail": "pharmacopoeial specification for nadroparin anti-Xa specific activity",
            "conditions": "pharmacopoeial specification for nadroparin anti-Xa specific activity",
            "conditions_detail": "pharmacopoeial specification for nadroparin anti-Xa specific activity | anti Xa anti IIa ratio: 2.5:1 to 4.0:1",
            "doi": "",
            "source_url": "https://www.sciencedirect.com/topics/nursing-and-health-professions/tinzaparin",
            "year": "2020",
            "confidence": "medium",
            "comments": "\"Nadroparin comprises an anti-Xa activity of not less than 95 IU mg-1 and not more than 130 IU mg-1, and/or a ratio of anti-Xa activity to anti-IIa activity of at least 2.5:1, and up to 4.0:1.\"  — Pharmacopoeial anti-Xa specific-activity range for nadroparin (no DOI; ScienceDirect Topics compilation page).  [ScienceDirect Topics (compilation), 2020, confidence: medium]"
        }
    ]
}