Glyco Property List
Pooled literature properties (glycanDB). Optional filters: ?dataset=uv_vis&property_key=...
GET /api/gdd/glyco-properties/?format=api&page=14
{ "count": 839, "next": "http://glycodata.org/api/gdd/glyco-properties/?format=api&page=15", "previous": "http://glycodata.org/api/gdd/glyco-properties/?format=api&page=13", "results": [ { "id": 261, "dataset": "carbohydrate", "entity": "methyl 2,4-di-O-methyl-alpha-D-galactopyranosiduronic acid (methyl ester)", "entity_group": "", "entity_class": "glycoside", "property": "pKa", "property_key": "pka", "value": "3.22", "unit": "pKa", "value_reported": "3.22", "unit_reported": "pKa", "method": "Experiment", "method_detail": "carboxyl pK, compound IV, 20 C, discontinuous potentiometric titration", "conditions": "carboxyl pK, compound IV, 20 C, discontinuous potentiometric titration", "conditions_detail": "carboxyl pK, compound IV, 20 C, discontinuous potentiometric titration | group: carboxyl | temperature C: 20", "doi": "", "source_url": "https://www.chemicalpapers.com/file_access.php?file=324a478.pdf", "year": "1978", "confidence": "high", "comments": "\"Table 1 ... Methyl 2,4-di-O-methyl-a-D-galactopyranosiduronic ... 3.22±0.01 ... ApK -0.29\" — Chem. Zvesti 32(4) 478-485 (1978), Table 1 compound IV. [Kohn, R.; Kovac, P., 1978, confidence: high]" }, { "id": 262, "dataset": "carbohydrate", "entity": "methyl 2,3-di-O-methyl-alpha-D-galactopyranosiduronic acid (methyl ester)", "entity_group": "", "entity_class": "glycoside", "property": "pKa", "property_key": "pka", "value": "3.42", "unit": "pKa", "value_reported": "3.42", "unit_reported": "pKa", "method": "Experiment", "method_detail": "carboxyl pK, compound V, 20 C, discontinuous potentiometric titration", "conditions": "carboxyl pK, compound V, 20 C, discontinuous potentiometric titration", "conditions_detail": "carboxyl pK, compound V, 20 C, discontinuous potentiometric titration | group: carboxyl | temperature C: 20", "doi": "", "source_url": "https://www.chemicalpapers.com/file_access.php?file=324a478.pdf", "year": "1978", "confidence": "high", "comments": "\"Table 1 ... Methyl 2,3-di-O-methyl-a-D-galactopyranosiduronic ... 3.42±0.01 ... ApK -0.09\" — Chem. Zvesti 32(4) 478-485 (1978), Table 1 compound V. [Kohn, R.; Kovac, P., 1978, confidence: high]" }, { "id": 263, "dataset": "carbohydrate", "entity": "methyl 2,3,4-tri-O-methyl-alpha-D-galactopyranosiduronic acid (methyl ester)", "entity_group": "", "entity_class": "glycoside", "property": "pKa", "property_key": "pka", "value": "3.13", "unit": "pKa", "value_reported": "3.13", "unit_reported": "pKa", "method": "Experiment", "method_detail": "carboxyl pK, compound VI (fully methylated D-galacturonic derivative), 20 C, discontinuous potentiometric titration", "conditions": "carboxyl pK, compound VI (fully methylated D-galacturonic derivative), 20 C, discontinuous potentiometric titration", "conditions_detail": "carboxyl pK, compound VI (fully methylated D-galacturonic derivative), 20 C, discontinuous potentiometric titration | group: carboxyl | temperature C: 20", "doi": "", "source_url": "https://www.chemicalpapers.com/file_access.php?file=324a478.pdf", "year": "1978", "confidence": "high", "comments": "\"Table 1 ... Methyl 2,3,4-tri-O-methyl-a-D-galactopyranosiduronic ... 3.13±0.01 ... ApK -0.38\" — Chem. Zvesti 32(4) 478-485 (1978), Table 1 compound VI; lowest pK of the galacto series. [Kohn, R.; Kovac, P., 1978, confidence: high]" }, { "id": 264, "dataset": "carbohydrate", "entity": "methyl 2,3,4-tri-O-methyl-alpha-D-glucopyranosiduronic acid (methyl ester)", "entity_group": "", "entity_class": "glycoside", "property": "pKa", "property_key": "pka", "value": "3.03", "unit": "pKa", "value_reported": "3.03", "unit_reported": "pKa", "method": "Experiment", "method_detail": "carboxyl pK, compound VIII (fully methylated D-glucuronic derivative), 20 C, discontinuous potentiometric titration", "conditions": "carboxyl pK, compound VIII (fully methylated D-glucuronic derivative), 20 C, discontinuous potentiometric titration", "conditions_detail": "carboxyl pK, compound VIII (fully methylated D-glucuronic derivative), 20 C, discontinuous potentiometric titration | group: carboxyl | temperature C: 20", "doi": "", "source_url": "https://www.chemicalpapers.com/file_access.php?file=324a478.pdf", "year": "1978", "confidence": "high", "comments": "\"Table 1 ... Methyl 2,3,4-tri-O-methyl-a-D-glucopyranosiduronic ... 3.03 ±0.02 ... ApK -0.25\" — Chem. Zvesti 32(4) 478-485 (1978), Table 1 compound VIII. [Kohn, R.; Kovac, P., 1978, confidence: high]" }, { "id": 265, "dataset": "carbohydrate", "entity": "4-deoxy-beta-L-threo-hex-4-enopyranuronic acid (methyl ester glycoside)", "entity_group": "", "entity_class": "uronic acid", "property": "pKa", "property_key": "pka", "value": "3.1", "unit": "pKa", "value_reported": "3.1", "unit_reported": "pKa", "method": "Experiment", "method_detail": "carboxyl pK, compound IX, 4,5-unsaturated uronic acid (pectate/pectin lyase product), 20 C, discontinuous potentiometric titration", "conditions": "carboxyl pK, compound IX, 4,5-unsaturated uronic acid (pectate/pectin lyase product), 20 C, discontinuous potentiometric titration", "conditions_detail": "carboxyl pK, compound IX, 4,5-unsaturated uronic acid (pectate/pectin lyase product), 20 C, discontinuous potentiometric titration | group: carboxyl | temperature C: 20", "doi": "", "source_url": "https://www.chemicalpapers.com/file_access.php?file=324a478.pdf", "year": "1978", "confidence": "high", "comments": "\"Table 1 ... Methyl 4-deoxy-j3-L-fhreo-hex-4-enopyranosiduronic ... 3.10±0.01 ... ApK -0.41\" — Chem. Zvesti 32(4) 478-485 (1978), Table 1 compound IX; unsaturated uronic acid formed by beta-elimination in pectin degradation. [Kohn, R.; Kovac, P., 1978, confidence: high]" }, { "id": 266, "dataset": "carbohydrate", "entity": "D-glucuronic acid", "entity_group": "", "entity_class": "uronic acid", "property": "pKa", "property_key": "pka", "value": "3.24", "unit": "pKa", "value_reported": "3.24", "unit_reported": "pKa", "method": "Experiment", "method_detail": "carboxyl pK, 25 C, literature value cited by Kohn & Kovac (ref [14], Zverev 1960)", "conditions": "carboxyl pK, 25 C, literature value cited by Kohn & Kovac (ref [14], Zverev 1960)", "conditions_detail": "carboxyl pK, 25 C, literature value cited by Kohn & Kovac (ref [14], Zverev 1960) | group: carboxyl | temperature C: 25", "doi": "", "source_url": "https://www.chemicalpapers.com/file_access.php?file=324a478.pdf", "year": "1978", "confidence": "medium", "comments": "\"The following pK values for D-glucuronic acid can be found in the literature: 3.33 [19], 3.20 [21], 3.24 (25°C) [14], 3.23 (25°C) [23]\" — Literature compilation value cited within Kohn & Kovac (1978); original ref [14] Zverev 1960. [Kohn, R.; Kovac, P., 1978, confidence: medium]" }, { "id": 267, "dataset": "carbohydrate", "entity": "D-galacturonic acid", "entity_group": "", "entity_class": "uronic acid", "property": "pKa", "property_key": "pka", "value": "3.47", "unit": "pKa", "value_reported": "3.47", "unit_reported": "pKa", "method": "Experiment", "method_detail": "carboxyl pK, 25 C, literature value cited by Kohn & Kovac (ref [23], Holvik & Hoiland 1977)", "conditions": "carboxyl pK, 25 C, literature value cited by Kohn & Kovac (ref [23], Holvik & Hoiland 1977)", "conditions_detail": "carboxyl pK, 25 C, literature value cited by Kohn & Kovac (ref [23], Holvik & Hoiland 1977) | group: carboxyl | temperature C: 25", "doi": "", "source_url": "https://www.chemicalpapers.com/file_access.php?file=324a478.pdf", "year": "1978", "confidence": "medium", "comments": "\"For D-galacturonic acid the following pK have been determined: 3.42 (27°C) [20], 3.42 [21], 3.49 (23.6°C) [22], 3.47 (25°C) [23]\" — Literature compilation value cited within Kohn & Kovac (1978); original ref [23] Holvik & Hoiland, J. Chem. Thermodyn. 9, 345 (1977). [Kohn, R.; Kovac, P., 1978, confidence: medium]" }, { "id": 268, "dataset": "carbohydrate", "entity": "D-galacturonic acid", "entity_group": "", "entity_class": "uronic acid", "property": "pKa", "property_key": "pka", "value": "3.51", "unit": "pKa", "value_reported": "3.51", "unit_reported": "pKa", "method": "Review", "method_detail": "carboxyl pKa of galacturonic acid, value cited in microbiology study of pectin fermentation", "conditions": "carboxyl pKa of galacturonic acid, value cited in microbiology study of pectin fermentation", "conditions_detail": "carboxyl pKa of galacturonic acid, value cited in microbiology study of pectin fermentation | group: carboxyl", "doi": "10.1128/AEM.07617-11", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC3416429/", "year": "2012", "confidence": "high", "comments": "\"Galacturonic acid is the uronic acid of galactose and has a dissociation constant (pKa) of 3.51\" — Independent secondary citation of the carboxyl pKa, consistent with Kohn & Kovac (1978). [Huisjes, E.H.; et al., 2012, confidence: high]" }, { "id": 269, "dataset": "carbohydrate", "entity": "alpha-L-idopyranosyluronic acid 2-sulphate (heparin iduronic acid)", "entity_group": "", "entity_class": "uronic acid", "property": "pKa", "property_key": "pka", "value": "3.13", "unit": "pKa", "value_reported": "3.13", "unit_reported": "pKa", "method": "Experiment", "method_detail": "carboxylate pKa determined using heparin, 13C-NMR spectroscopy at various pH", "conditions": "carboxylate pKa determined using heparin, 13C-NMR spectroscopy at various pH", "conditions_detail": "carboxylate pKa determined using heparin, 13C-NMR spectroscopy at various pH | group: carboxyl", "doi": "10.1042/bj2780689", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC1151401/", "year": "1991", "confidence": "high", "comments": "\"The pKa values of their carboxylate groups were determined as 3.13 (using heparin), 2.79 (using heparin) and 3.0 (predicted by using model compounds) respectively\" — Biochem J 278(Pt 3):689-695. alpha-L-IdoA 2-sulphate residue in heparin. [Wang, H.M.; Loganathan, D.; Linhardt, R.J., 1991, confidence: high]" }, { "id": 270, "dataset": "carbohydrate", "entity": "beta-D-glucopyranosyluronic acid (heparin glucuronic acid)", "entity_group": "", "entity_class": "uronic acid", "property": "pKa", "property_key": "pka", "value": "2.79", "unit": "pKa", "value_reported": "2.79", "unit_reported": "pKa", "method": "Experiment", "method_detail": "carboxylate pKa determined using heparin, 13C-NMR spectroscopy at various pH", "conditions": "carboxylate pKa determined using heparin, 13C-NMR spectroscopy at various pH", "conditions_detail": "carboxylate pKa determined using heparin, 13C-NMR spectroscopy at various pH | group: carboxyl", "doi": "10.1042/bj2780689", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC1151401/", "year": "1991", "confidence": "high", "comments": "\"The pKa values of their carboxylate groups were determined as 3.13 (using heparin), 2.79 (using heparin) and 3.0 (predicted by using model compounds) respectively\" — Biochem J 278(Pt 3):689-695. beta-D-GlcA residue in heparin. [Wang, H.M.; Loganathan, D.; Linhardt, R.J., 1991, confidence: high]" }, { "id": 271, "dataset": "carbohydrate", "entity": "alpha-L-idopyranosyluronic acid (heparin, predicted)", "entity_group": "", "entity_class": "uronic acid", "property": "pKa", "property_key": "pka", "value": "3", "unit": "pKa", "value_reported": "3.0", "unit_reported": "pKa", "method": "Experiment", "method_detail": "carboxylate pKa predicted using model compounds (13C-NMR study of heparin)", "conditions": "carboxylate pKa predicted using model compounds (13C-NMR study of heparin)", "conditions_detail": "carboxylate pKa predicted using model compounds (13C-NMR study of heparin) | group: carboxyl", "doi": "10.1042/bj2780689", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC1151401/", "year": "1991", "confidence": "medium", "comments": "\"and 3.0 (predicted by using model compounds) respectively\" — Biochem J 278(Pt 3):689-695. Value is predicted (not directly measured) for non-sulphated alpha-L-IdoA in heparin. [Wang, H.M.; Loganathan, D.; Linhardt, R.J., 1991, confidence: medium]" }, { "id": 272, "dataset": "carbohydrate", "entity": "N-acetylneuraminic acid (Neu5Ac, sialic acid)", "entity_group": "", "entity_class": "sialic acid", "property": "pKa", "property_key": "pka", "value": "2.6", "unit": "pKa", "value_reported": "2.6", "unit_reported": "pKa", "method": "Review", "method_detail": "C-1 carboxylate pKa of Neu5Ac; the electron-withdrawing carboxylate is attached to the C-2 anomeric carbon", "conditions": "C-1 carboxylate pKa of Neu5Ac; the electron-withdrawing carboxylate is attached to the C-2 anomeric carbon", "conditions_detail": "C-1 carboxylate pKa of Neu5Ac; the electron-withdrawing carboxylate is attached to the C-2 anomeric carbon | group: carboxyl", "doi": "10.1101/glycobiology.4e.15", "source_url": "https://www.ncbi.nlm.nih.gov/books/NBK579976/", "year": "2022", "confidence": "high", "comments": "\"The most common Sia form in humans is Neu5Ac, a relatively strong acid (pKa=2.6) with the electron-withdrawing C-1 carboxylate attached to the C-2 anomeric carbon.\" — Reference textbook (Cold Spring Harbor). Lower pKa than typical carboxylic acids due to adjacent ring oxygen / anomeric carbon. [Lewis, A.L.; Chen, X.; Schnaar, R.L.; Varki, A., 2022, confidence: high]" }, { "id": 273, "dataset": "carbohydrate", "entity": "L-ascorbic acid (vitamin C)", "entity_group": "", "entity_class": "sugar acid", "property": "pKa", "property_key": "pka", "value": "4.17", "unit": "pKa", "value_reported": "4.17", "unit_reported": "pKa", "method": "Experiment", "method_detail": "pK1 (first dissociation, C-3 enediol OH), from Merck Index compilation", "conditions": "pK1 (first dissociation, C-3 enediol OH), from Merck Index compilation", "conditions_detail": "pK1 (first dissociation, C-3 enediol OH), from Merck Index compilation | group: enediol_OH", "doi": "", "source_url": "https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/54670067/JSON?heading=Dissociation+Constants", "year": "2006", "confidence": "high", "comments": "\"pK1 = 4.17; pK2 = 11.57\" — Ascorbic acid is a sugar acid (lactone of a hexonic acid); first proton is the C-3 enediol OH. [O'Neil, M.J. (ed.), The Merck Index, 14th ed. (2006), p. 136, 2006, confidence: high]" }, { "id": 274, "dataset": "carbohydrate", "entity": "L-ascorbic acid (vitamin C)", "entity_group": "", "entity_class": "sugar acid", "property": "pKa", "property_key": "pka", "value": "11.57", "unit": "pKa", "value_reported": "11.57", "unit_reported": "pKa", "method": "Experiment", "method_detail": "pK2 (second dissociation, C-2 enediol OH), from Merck Index compilation", "conditions": "pK2 (second dissociation, C-2 enediol OH), from Merck Index compilation", "conditions_detail": "pK2 (second dissociation, C-2 enediol OH), from Merck Index compilation | group: enediol_OH", "doi": "", "source_url": "https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/54670067/JSON?heading=Dissociation+Constants", "year": "2006", "confidence": "high", "comments": "\"pK1 = 4.17; pK2 = 11.57\" — Second (much weaker) ionization of ascorbic acid. [O'Neil, M.J. (ed.), The Merck Index, 14th ed. (2006), p. 136, 2006, confidence: high]" }, { "id": 275, "dataset": "carbohydrate", "entity": "L-ascorbic acid (vitamin C)", "entity_group": "", "entity_class": "sugar acid", "property": "pKa", "property_key": "pka", "value": "4.7", "unit": "pKa", "value_reported": "4.7", "unit_reported": "pKa", "method": "Experiment", "method_detail": "pKa at 10 C, IUPAC compilation (Kortum et al. 1961)", "conditions": "pKa at 10 C, IUPAC compilation (Kortum et al. 1961)", "conditions_detail": "pKa at 10 C, IUPAC compilation (Kortum et al. 1961) | group: enediol_OH | temperature C: 10", "doi": "", "source_url": "https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/54670067/JSON?heading=Dissociation+Constants", "year": "1961", "confidence": "high", "comments": "\"pKa = 4.70 at 10 °C\" — Temperature 10 C (hence higher than the 25 C value of 4.17); first dissociation. [Kortum, G.; Vogel, W.; Andrussow, K. (IUPAC, Dissociation Constants of Organic Acids in Aqueous Solution, Butterworth, 1961), 1961, confidence: high]" }, { "id": 276, "dataset": "carbohydrate", "entity": "D-gluconic acid", "entity_group": "", "entity_class": "sugar acid", "property": "pKa", "property_key": "pka", "value": "3.62", "unit": "pKa", "value_reported": "3.62", "unit_reported": "pKa", "method": "Experiment", "method_detail": "carboxyl pKa (acidic), ChEMBL value reported in PubChem Dissociation Constants section", "conditions": "carboxyl pKa (acidic), ChEMBL value reported in PubChem Dissociation Constants section", "conditions_detail": "carboxyl pKa (acidic), ChEMBL value reported in PubChem Dissociation Constants section | group: carboxyl", "doi": "", "source_url": "https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/10690/JSON?heading=Dissociation+Constants", "year": "2025", "confidence": "high", "comments": "\"Acidic pKa: 3.62 ... Tested as SID 103629256 in AID 781325\" — D-gluconic acid is an aldonic acid (oxidation product of glucose at C-1). [ChEMBL (via PubChem), 2025, confidence: high]" }, { "id": 277, "dataset": "carbohydrate", "entity": "D-gluconic acid", "entity_group": "", "entity_class": "sugar acid", "property": "pKa", "property_key": "pka", "value": "3.6", "unit": "pKa", "value_reported": "3.6", "unit_reported": "pKa", "method": "Experiment", "method_detail": "carboxyl pKa derived from Ka = 2.5e-4 at 25 C (Merck Index); pKa = -log10(2.5e-4) = 3.60", "conditions": "carboxyl pKa derived from Ka = 2.5e-4 at 25 C (Merck Index); pKa = -log10(2.5e-4) = 3.60", "conditions_detail": "carboxyl pKa derived from Ka = 2.5e-4 at 25 C (Merck Index); pKa = -log10(2.5e-4) = 3.60 | group: carboxyl | temperature C: 25", "doi": "", "source_url": "https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/10690/JSON?heading=Dissociation+Constants", "year": "1989", "confidence": "high", "comments": "\"Ka value: 2.5×10⁻⁴ @ 25°C\" — pKa computed from the reported Ka (2.5e-4) at 25 C; consistent with the ChEMBL value 3.62. [Budavari, S. (ed.), The Merck Index, 11th ed., 1989, confidence: high]" }, { "id": 278, "dataset": "carbohydrate", "entity": "D-glucaric acid (saccharic acid)", "entity_group": "", "entity_class": "sugar acid", "property": "pKa", "property_key": "pka", "value": "3.01", "unit": "pKa", "value_reported": "3.01", "unit_reported": "pKa", "method": "Review", "method_detail": "pKa1, first carboxyl dissociation of the aldaric (dicarboxylic) acid", "conditions": "pKa1, first carboxyl dissociation of the aldaric (dicarboxylic) acid", "conditions_detail": "pKa1, first carboxyl dissociation of the aldaric (dicarboxylic) acid | group: carboxyl", "doi": "", "source_url": "https://grokipedia.com/page/Saccharic_acid", "year": "2025", "confidence": "low", "comments": "\"Saccharic acid (also known as D-glucaric acid) has pKa values of 3.01 and 3.94\" — Aldaric acid with two carboxyl groups. Secondary compilation source; pKa1 of the diprotic acid. Confidence low pending a primary potentiometric reference. [Grokipedia (Saccharic acid), 2025, confidence: low]" }, { "id": 279, "dataset": "carbohydrate", "entity": "D-glucaric acid (saccharic acid)", "entity_group": "", "entity_class": "sugar acid", "property": "pKa", "property_key": "pka", "value": "3.94", "unit": "pKa", "value_reported": "3.94", "unit_reported": "pKa", "method": "Review", "method_detail": "pKa2, second carboxyl dissociation of the aldaric (dicarboxylic) acid", "conditions": "pKa2, second carboxyl dissociation of the aldaric (dicarboxylic) acid", "conditions_detail": "pKa2, second carboxyl dissociation of the aldaric (dicarboxylic) acid | group: carboxyl", "doi": "", "source_url": "https://grokipedia.com/page/Saccharic_acid", "year": "2025", "confidence": "low", "comments": "\"Saccharic acid (also known as D-glucaric acid) has pKa values of 3.01 and 3.94\" — Second carboxyl dissociation. Secondary compilation source; confidence low pending a primary reference. [Grokipedia (Saccharic acid), 2025, confidence: low]" }, { "id": 280, "dataset": "carbohydrate", "entity": "D-glucosamine", "entity_group": "", "entity_class": "amino sugar", "property": "pKa", "property_key": "pka", "value": "7.58", "unit": "pKa", "value_reported": "7.58", "unit_reported": "pKa", "method": "Experiment", "method_detail": "protonated amino group (NH3+) pKa; value from Bichsel & Von Gunten (2000)", "conditions": "protonated amino group (NH3+) pKa; value from Bichsel & Von Gunten (2000)", "conditions_detail": "protonated amino group (NH3+) pKa; value from Bichsel & Von Gunten (2000) | group: amino", "doi": "10.1021/es9914590", "source_url": "https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/439213/JSON?heading=Dissociation+Constants", "year": "2000", "confidence": "high", "comments": "\"pKa = 7.58 ... Bichsel Y, Von Gunten U; Environ Sci Technol 34: 2784-91 (2000)\" — Amino sugar; ionizable group is the C-2 ammonium. [Bichsel, Y.; Von Gunten, U., Environ. Sci. Technol. 34, 2784-2791, 2000, confidence: high]" } ] }